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collagenase Clostridium histolyticum

Known as: collagenase I, Clostridium histolyticum Collagenase, Collagenase, Microbial 
A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro… 
National Institutes of Health

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16 relations
Burn injuryCOLLAGENASECOLLAGENASE 0.25 UNT/MG Topical OintmentDrug Allergy

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Papers overview

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Highly Cited
2000
Highly Cited
2000
Protease inhibitors: synthesis of potent bacterial collagenase and matrix metalloproteinase inhibitors incorporating N-4-nitrobenzylsulfonylglycine hydroxamate moieties.
A series of compounds was prepared by reaction of alkyl/arylsulfonyl halides with N-4-nitrobenzylglycine, followed by conversion… 
Highly Cited
1999
Highly Cited
1999
Mechanical loading of bovine pericardium accelerates enzymatic degradation.
Highly Cited
1992
Highly Cited
1992
Kinetics of hydrolysis of type I, II, and III collagens by the class I and IIClostridium histolyticum collagenases
The kinetics of hydrolysis of rat tendon type I, bovine nasal septum type II, and human placental type III collagens by class I… 
1985
1985
Cleavage of bovine skin type III collagen by proteolytic enzymes. Relative resistance of the fibrillar form.
We have studied the susceptibility of fibrils formed from fetal bovine skin type III collagen to proteolytic enzymes known to… 
Highly Cited
1984
Highly Cited
1984
Rapid purification of a cloned gene product by genetic fusion and site-specific proteolysis.
We have developed a rapid and general technique for purification of a protein encoded by a cistron contained in a recombinant DNA… 
1975
1975
Application of affinity chromatography to the purification of collagenase for the isolation of insoluble elastin.
1970
1970
Circular dichroism of proteins of known and unknown conformations.
Highly Cited
1959
Highly Cited
1959
Studies on collagen. II. Properties of purified collagenase and its inhibition.
In previous papers from these laboratories (1, 2) methods for the purification of the collagenase of Clostridiurm histolyticum… 
Highly Cited
1959
Highly Cited
1959
Studies on the collagenases of Clostridium histolyticum.
1950
1950
Production, Purification, and Some Properties of Clostridium histolyticum Collagenase.∗
Jennison(1) reported that Clostridium histolyticum produced a proteinase that was able to digest “native” collagen. In a previous… 
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