collagenase Clostridium histolyticum

Known as: collagenase I, Clostridium histolyticum Collagenase, Collagenase, Microbial 
A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro… (More)
National Institutes of Health

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Topic mentions per year

1959-2018
0102019592018

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15 relations
Burn injuryCOLLAGENASE 0.25 UNT/MG Topical OintmentDrug AllergyEnzyme Activators [MoA]
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Broader (1)

COLLAGENASE

Narrower (2)

Xiaflexiruxol

Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
collagenase Clostridium histolyticum
Drug Allergy
standards characteristics
physiological aspects
Burn injury
COLLAGENASE

Papers overview

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2016
2016
Restoration of Penile Function and Patient Satisfaction with Intralesional Collagenase Clostridium Histolyticum Injection for Peyronie's Disease.
PURPOSE Collagenase clostridium histolyticum is approved for the treatment of Peyronie's disease. To date, no post-release study… (More)
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2015
2015
Clinical safety and effectiveness of collagenase clostridium histolyticum injection in patients with Peyronie's disease: a phase 3 open-label study.
INTRODUCTION Collagenase clostridium histolyticum (CCH; Xiaflex, Auxilium Pharmaceuticals, Inc., Chesterbrook, PA, USA) is a Food… (More)
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2015
2015
Injectable collagenase Clostridium histolyticum as a nonsurgical treatment for Dupuytren’s disease
Nonsurgical treatment of Dupuytren’s disease using collagenase Clostridium histolyticum (CCH). Metacarpophalangeal (MP) joint (20… (More)
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2015
2015
Delayed manipulation after collagenase clostridium histolyticum injection for Dupuytren contracture.
BACKGROUND Collagenase clostridium histolyticum (CCH) injection for Dupuytren contracture was approved in the USA in 2010… (More)
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2015
2015
Collagenase Clostridium histolyticum for the pharmacological management of Peyronie's disease.
Peyronie's disease (PD) is defined as the abnormal accumulation of connective tissue in the tunica albuginea of the penis, and is… (More)
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2013
2013
Dupuytren contracture recurrence following treatment with collagenase clostridium histolyticum (CORDLESS study): 3-year data.
PURPOSE To evaluate long-term efficacy and safety of collagenase clostridium histolyticum (CCH) after the third year of a 5-year… (More)
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2013
2013
Efficacy and safety of collagenase clostridium histolyticum injection for Dupuytren contracture: short-term results from 2 open-label studies.
PURPOSE The JOINT I (United States) and JOINT II (Australia and Europe) studies evaluated the efficacy and safety of collagenase… (More)
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Highly Cited
2009
Highly Cited
2009
Injectable collagenase clostridium histolyticum for Dupuytren's contracture.
BACKGROUND Dupuytren's disease limits hand function, diminishes the quality of life, and may ultimately disable the hand. Surgery… (More)
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1999
1999
Gene duplication and multiplicity of collagenases in Clostridium histolyticum.
Clostridium histolyticum collagenase contains a number of different active components. Previously we have shown that colH encodes… (More)
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1998
1998
A study of the collagen-binding domain of a 116-kDa Clostridium histolyticum collagenase.
The Clostridium histolyticum 116-kDa collagenase consists of four segments, S1, S2a, S2b, and S3. A 98-kDa gelatinase, which can… (More)
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