collagenase Clostridium histolyticum

Known as: collagenase I, Clostridium histolyticum Collagenase, Collagenase, Microbial 
A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1959-2018
0102019592018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
PURPOSE Collagenase clostridium histolyticum is approved for the treatment of Peyronie's disease. To date, no post-release study… (More)
Is this relevant?
2015
2015
INTRODUCTION Collagenase clostridium histolyticum (CCH; Xiaflex, Auxilium Pharmaceuticals, Inc., Chesterbrook, PA, USA) is a Food… (More)
  • figure 1
  • table 1
  • figure 2
  • table 2
  • table 3
Is this relevant?
2015
2015
Nonsurgical treatment of Dupuytren’s disease using collagenase Clostridium histolyticum (CCH). Metacarpophalangeal (MP) joint (20… (More)
  • figure 19
  • figure 28
  • figure 38
  • figure 48
  • figure 58
Is this relevant?
2015
2015
BACKGROUND Collagenase clostridium histolyticum (CCH) injection for Dupuytren contracture was approved in the USA in 2010… (More)
Is this relevant?
2015
2015
Peyronie's disease (PD) is defined as the abnormal accumulation of connective tissue in the tunica albuginea of the penis, and is… (More)
Is this relevant?
2013
2013
PURPOSE To evaluate long-term efficacy and safety of collagenase clostridium histolyticum (CCH) after the third year of a 5-year… (More)
Is this relevant?
2013
2013
PURPOSE The JOINT I (United States) and JOINT II (Australia and Europe) studies evaluated the efficacy and safety of collagenase… (More)
Is this relevant?
Highly Cited
2009
Highly Cited
2009
BACKGROUND Dupuytren's disease limits hand function, diminishes the quality of life, and may ultimately disable the hand. Surgery… (More)
  • figure 1
  • figure 1
Is this relevant?
1999
1999
Clostridium histolyticum collagenase contains a number of different active components. Previously we have shown that colH encodes… (More)
  • figure 1
  • figure 3
  • table 1
  • figure 4
  • figure 5
Is this relevant?
1998
1998
The Clostridium histolyticum 116-kDa collagenase consists of four segments, S1, S2a, S2b, and S3. A 98-kDa gelatinase, which can… (More)
Is this relevant?