Skip to search formSkip to main contentSkip to account menu

collagenase Clostridium histolyticum

Known as: collagenase I, Clostridium histolyticum Collagenase, Collagenase, Microbial 
A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro… 
National Institutes of Health

Related topics

Related topics

16 relations
Burn injuryCOLLAGENASECOLLAGENASE 0.25 UNT/MG Topical OintmentDrug Allergy

Narrower (2)

Xiaflexiruxol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Collagenase Clostridium histolyticum : emerging practice patterns and treatment advances
Abstract Objective: This study aims to provide a comprehensive review of the role of Collagenase Clostridium histolyticum (CCH… 
Highly Cited
2015
Highly Cited
2015
Dupuytren Contracture Recurrence Following Treatment With Collagenase Clostridium histolyticum (CORDLESS [Collagenase Option for Reduction of Dupuytren Long-Term Evaluation of Safety Study]): 5-Year…
Highly Cited
2015
Highly Cited
2015
Clinical safety and effectiveness of collagenase clostridium histolyticum injection in patients with Peyronie's disease: a phase 3 open-label study.
INTRODUCTION Collagenase clostridium histolyticum (CCH; Xiaflex, Auxilium Pharmaceuticals, Inc., Chesterbrook, PA, USA) is a Food… 
Review
2015
Review
2015
Safety and tolerability of collagenase Clostridium histolyticum and fasciectomy for Dupuytren’s contracture
Safety was evaluated for collagenase Clostridium histolyticum (CCH) based on 11 clinical trials (N = 1082) and compared with… 
Highly Cited
2003
Highly Cited
2003
Inhibition of collagenase and metalloproteinases by aloins and aloe gel.
Highly Cited
1995
Highly Cited
1995
Crystal structures of recombinant 19-kDa human fibroblast collagenase complexed to itself.
Collagenase is a member of the matrix metalloproteinase (MMP) family of enzymes. Aberrant regulation of this family has been… 
Highly Cited
1992
Highly Cited
1992
Identification and functional characterization of a TIA-1-related nucleolysin.
We recently reported the molecular cloning of a cytotoxic granule-associated RNA-binding protein designated TIA-1. The ability of… 
Highly Cited
1984
Highly Cited
1984
Rapid purification of a cloned gene product by genetic fusion and site-specific proteolysis.
We have developed a rapid and general technique for purification of a protein encoded by a cistron contained in a recombinant DNA… 
Highly Cited
1977
Highly Cited
1977
Enzyme-accelerated hydrolysis of polyglycolic acid.
In a preliminary study of the enzyme-polymer interactions, the role of 15 enzymes in the in vitro hydrolysis of polyglycolic acid… 
Highly Cited
1959
Highly Cited
1959
Studies on collagen. II. Properties of purified collagenase and its inhibition.
In previous papers from these laboratories (1, 2) methods for the purification of the collagenase of Clostridiurm histolyticum… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)