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cicletanine

Known as: Cycletanide, Furo(3,4-c)pyridin-7-ol, 3-(4-chlorophenyl)-1,3-dihydro-6-methyl-, cicletanide 
A dihydropyridine derivative with diuretic and antihypertensive activity. Cicletanine exerts thiazide-like diuretic activity. In addition, this agent… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (4)

Anti-Arrhythmia AgentsAntihypertensive AgentsDiureticsPyridines

Narrower (2)

CICLETANINE HCLTenstaten

Papers overview

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2013
2013
Cicletanine stimulates eNOS phosphorylation and NO production via Akt and MAP kinase/Erk signaling in sinusoidal endothelial cells.
The function of the endothelial isoform of nitric oxide synthase (eNOS) and production of nitric oxide (NO) is altered in a… 
Highly Cited
2001
Highly Cited
2001
Nitric Oxide, Peroxynitrite and cGMP in Atherosclerosis-Induced Hypertension in Rabbits: Beneficial Effects of Cicletanine
We studied the effect of the furopyridine derivative antihypertensive drug, cicletanine, on blood pressure, vascular nitric oxide… 
1990
1990
Inhibition of Low Km Cyclic GMP Phosphodiesterases and Potentiation of Guanylate Cyclase Activators by Cicletanine
Cicletanine is an antihypertensive/vasorelaxant/natriuretic agent of unknown mechanism. We wished (a) to determine if cicletanine… 
1989
1989
Modifications of the Arterial Mechanical Properties of Normotensive and Hypertensive Rats Without Arterial Pressure Changes
Possible reduction in arterial thickness may be an interesting way to reduce left ventricular afterload in various pathologie… 
1988
1988
Comparison of cicletanine with other antihypertensive drugs in SHR-SP models.
The effects of cicletanine were compared with those of four other antihypertensive drugs (prazosin, a highly selective alpha 1… 
1988
1988
General pharmacology of cicletanine.
Cicletanine is a new antihypertensive molecule which acts directly on vascular smooth muscle by increasing prostacyclin synthesis… 
1987
1987
Competitive and stereoselective histamine H1 antagonistic effect of cicletanide in guinea-pig isolated ileum.
1986
1986
Cicletanide Improves Outcome After Left Circumflex Coronary Artery Occlusion-Reperfusion in the Dog
Summary: The possible antifibrillatory effect of cicletanide, a new diuretic antihypertensive drug, was investigated at random in… 
1985
1985
Study of the effects of cicletanine on prostanoids.
The effect of cicletanine (BN 1270), a new furopyridine derivative, on human prostaglandin metabolism was investigated in a… 
1984
1984
Activation of prostacyclin synthesis in cultured aortic smooth muscle cells by 'diuretic-antihypertensive' drugs.
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