P. Ferdinandy

Publications430
h-index66
Citations16,137
Highly Influential Citations462
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • G. Heusch
  • 906 Publications • 42,854 Citations
  • R. Schulz
  • 497 Publications • 27,397 Citations
  • D. Yellon
  • 601 Publications • 43,219 Citations
  • D. Hausenloy
  • 507 Publications • 31,108 Citations
  • Publications
  • Influence
Interaction of Cardiovascular Risk Factors with Myocardial Ischemia/Reperfusion Injury, Preconditioning, and Postconditioning
TLDR
The aim of this review is to show the potential for developing cardioprotective drugs on the basis of endogenousCardioprotection by pre- and postconditioning and to review the evidence that comorbidities and aging accompanying coronary disease modify responses to ischemia/reperfusion and the cardiop Rotection conferred by preconditioning and post conditioning.
View on Publisher
Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology.
TLDR
Understanding of the underlying mechanisms must be improved to develop new therapeutic strategies to be applied at reperfusion with the ultimate aim of limiting the burden of ischaemic heart disease and potentially providing protection for other organs at risk of reperfusions injury, such as brain and kidney.
View on PubMed
Interaction of Risk Factors, Comorbidities, and Comedications with Ischemia/Reperfusion Injury and Cardioprotection by Preconditioning, Postconditioning, and Remote Conditioning
TLDR
The critical need to take into account the presence of cardiovascular risk factors and concomitant medications when designing preclinical studies for the identification and validation of cardioprotective drug targets and clinical studies is emphasized.
View on Publisher
Drug-induced mitochondrial dysfunction and cardiotoxicity.
TLDR
The mechanisms of mitochondrion-mediated cardiotoxicity of commonly used drugs and some potential cardioprotective strategies to prevent these toxicities are discussed.
View on PubMed
Cigarette smoke-induced proinflammatory alterations in the endothelial phenotype: role of NAD(P)H oxidase activation.
TLDR
It is proposed that water-soluble components of cigarette smoke activate the vascular NAD(P)H oxidase, leading to proinflammatory alterations in vascular phenotype, which likely promotes development of atherosclerosis, especially if other risk factors are also present.
View on PubMed
Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure.
TLDR
It is hypothesized that peroxynitrite itself is responsible for cytokine-induced cardiac depression, and stimulated the concerted enhancement in superoxide and NO-generating activities in the heart, thereby enhancing peroxlynitrite generation, which causes myocardial contractile failure.
View on PubMed
Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection
TLDR
This is the first study to show co-purification and in vitro association of LDL with extracellular vesicles and its interference with vesicle analysis, and the data point to the importance of careful study design and data interpretation in studies using blood-derived extrace Cellular Vesicle isolation and purification methods.
View on PubMed
Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles.
View on PubMed
Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods
TLDR
It is shown that it is feasible to isolate exosomes from blood plasma by SEC without significant albumin contamination albeit with low vesicle yield.
View PDF
Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia‐reperfusion injury and preconditioning
TLDR
The roles of NO, O2−·, and ONOO− in both ischaemia‐reperfusion injury and preconditioning are reviewed to resolve the apparent controversy over whether nitric oxide plays a protective or detrimental role.
View on Wiley
...
...