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Perspectives in platelet-activating factor research.
Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia.
- S. Adnot, B. Raffestin, S. Eddahibi, P. Braquet, P. Chabrier
- Biology, MedicineThe Journal of clinical investigation
It is demonstrated that hypoxia-induced pulmonary hypertension is associated with a loss of EDRF activity in pulmonary vessels, with a rapid recovery on return to a normoxic environment.
Distinct platelet-activating factor binding sites in synaptic endings and in intracellular membranes of rat cerebral cortex.
Ischemia and reperfusion-induced histologic changes in the rat retina. Demonstration of a free radical-mediated mechanism.
- M. Szabo, M. Droy-lefaix, M. Doly, C. Carré, P. Braquet
- Medicine, BiologyInvestigative ophthalmology & visual science
- 1 April 1991
The SOD and EGB 761 significantly reduced the development of reperfusion-induced retinal edema and significantly prevented the neutrophil leukocyte infiltration and had a protective effect against reperfusions-induced injury when these agents were administered just before reperfuse ("late" administration).
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets.
The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis.
Ligation of CD23 triggers cAMP generation and release of inflammatory mediators in human monocytes.
Results indicate that ligation of CD23 induces cAMP generation in CD23+ human monocytes and that CD23 may regulate the IgE-dependent functions in normal human monocyte.
BN 52021 and related compounds: A new series of highly specific PAF-acether receptor antagonists isolated from Ginkgo biloba L.
PAF-acether is one of the most powerful platelet activators known inducing platelet shape change, aggregation and secretion and reduces coronary blood flow and contractile force of isolated guineapig hearth, leading to cardiac anaphylaxis.
PAF-acether specific binding sites: 2. Design of specific antagonists