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A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension

• Songling Liu, Richard T Premont, Christopher D. Kontos, Shoukang Zhu, Don C. Rockey
• Nature Medicine
• 2005

Nitric oxide (NO) production by endothelial cell nitric oxide synthase (eNOS) in sinusoidal endothelial cells is reduced in the injured liver and leads to intrahepatic portal hypertension. We sought… (More)

Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt.

• Songling Liu, Richard T Premont, Christopher D. Kontos, Jianhua Huang, Don C. Rockey
• The Journal of biological chemistry
• 2003

Endothelin-1 has dual vasoactive effects, mediating vasoconstriction via ETA receptor activation of vascular smooth muscle cells and vasorelaxation via ETB receptor activation of endothelial cells.… (More)

Regulation of peroxisome proliferator-activated receptor-gamma in liver fibrosis.

• Che-Chang Chan, Oh-Sang Kwon, +6 authors Don C. Rockey
• American journal of physiology. Gastrointestinal…
• 2006

The peroxisome proliferator-activated receptors (PPARs) impart diverse cellular effects in biological systems. Because stellate cell activation during liver injury is associated with declining… (More)

Endothelial nitric-oxide synthase (eNOS) is activated through G-protein-coupled receptor kinase-interacting protein 1 (GIT1) tyrosine phosphorylation and Src protein.

• Songling Liu, Richard T Premont, Don C. Rockey
• The Journal of biological chemistry
• 2014

Nitric oxide (NO) is a critical regulator of vascular tone and plays an especially prominent role in liver by controlling portal blood flow and pressure within liver sinusoids. Synthesis of NO in… (More)

G-protein-coupled receptor kinase interactor-1 (GIT1) is a new endothelial nitric-oxide synthase (eNOS) interactor with functional effects on vascular homeostasis.

• Songling Liu, Richard T Premont, Don C. Rockey
• The Journal of biological chemistry
• 2012

Endothelial cell nitric-oxide (NO) synthase (eNOS), the enzyme responsible for synthesis of NO in the vasculature, undergoes extensive post-translational modifications that modulate its activity.… (More)

Association of age-dependent liver injury and fibrosis with immune cell populations.

• Bradley H. Collins, Zoie E. Holzknecht, +5 authors Don C. Rockey
• Liver international : official journal of the…
• 2013

BACKGROUND & AIMS The liver's response to injury is fibrosis, and when chronic, cirrhosis. Age is a critical factor impacting many immune-mediated processes, potentially including the liver's… (More)

Cicletanine stimulates eNOS phosphorylation and NO production via Akt and MAP kinase/Erk signaling in sinusoidal endothelial cells.

• Songling Liu, Don C. Rockey
• American journal of physiology. Gastrointestinal…
• 2013

The function of the endothelial isoform of nitric oxide synthase (eNOS) and production of nitric oxide (NO) is altered in a number of disease states. Pharmacological approaches to enhancing NO… (More)

PKCα regulates TMEM16A-mediated Cl⁻ secretion in human biliary cells.

• Amal K Dutta, Al-karim Khimji, +5 authors Andrew P. Feranchak
• American journal of physiology. Gastrointestinal…
• 2016

TMEM16A is a newly identified Ca(2+)-activated Cl(-) channel in biliary epithelial cells (BECs) that is important in biliary secretion. While extracellular ATP stimulates TMEM16A via binding P2… (More)

Caveolin 1 and G-Protein-Coupled Receptor Kinase-2 Coregulate Endothelial Nitric Oxide Synthase Activity in Sinusoidal Endothelial Cells.

• Songling Liu, Richard T Premont, Shweta Singh, Don C. Rockey
• The American journal of pathology
• 2017

Liver injury leads to a vasculopathy in which post-translational modifications of endothelial nitric oxide synthase (eNOS) lead to impaired nitric oxide synthesis. We hypothesized that caveolin 1… (More)

Caveolin-1 is upregulated in hepatic stellate cells but not sinusoidal endothelial cells after liver injury.

• Shweta Singh, Songling Liu, Don C. Rockey
• Tissue & cell
• 2016

Sinusoidal endothelial cells (SEC) and hepatic stellate cells (HSC) are closely associated specialized vascular cells residing in the hepatic sinusoid. These cells have been shown to play important… (More)

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