chromosome loss

Errors in chromosome segregation during mitosis result in aneuploidy, which in humans may play a role in the onset of neoplasia… Expand

Cse4p is an essential histone H3 variant in Saccharomyces cerevisiae that defines centromere identity and is required for proper… Expand

The detection of a low level 45,X cell line during routine cytogenetic analysis in an adult female can be difficult to interpret… Expand

The study of DNA damage at the chromosome level is an essential part of genetic toxicology because chromosomal mutation is an… Expand

Genotoxicity testing aims to detect a large range of genetic damage endpoints and evaluate such results in context of cell… Expand

Efficient genetic recombination requires near-perfect homology between participating molecules. Sequence divergence reduces the… Expand

Although basal cell carcinomas and squamous cell carcinomas are clinically and pathologically distinct, the molecular basis for… Expand

Yeast strains were constructed in which a single telomere could be eliminated from the end of a dispensable chromosome. In wild… Expand

We describe a general assay designed to detect mutants of yeast that are defective for any of several aspects of telomere… Expand

Whole chromosomes within micronuclei (MN) in cytokinesis-blocked human lymphocytes were detected by using anti-kinetochore… Expand