chromosome loss

Errors in chromosome segregation during mitosis result in aneuploidy, which in humans may play a role in the onset of neoplasia… (More)

The detection of a low level 45,X cell line during routine cytogenetic analysis in an adult female can be difficult to interpret… (More)

UNLABELLED Recent work has demonstrated enhanced X monosomy in women with primary biliary cirrhosis (PBC) as well as two other… (More)

Cohesion between sister chromatids is established during DNA replication and depends on a protein complex called cohesin. At the… (More)

The study of DNA damage at the chromosome level is an essential part of genetic toxicology because chromosomal mutation is an… (More)

Genotoxicity testing aims to detect a large range of genetic damage endpoints and evaluate such results in context of cell… (More)

Efficient genetic recombination requires near-perfect homology between participating molecules. Sequence divergence reduces the… (More)

Although basal cell carcinomas and squamous cell carcinomas are clinically and pathologically distinct, the molecular basis for… (More)

Yeast strains were constructed in which a single telomere could be eliminated from the end of a dispensable chromosome. In wild… (More)

We describe a general assay designed to detect mutants of yeast that are defective for any of several aspects of telomere… (More)