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DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice.
- G. Gamboa da Costa, M. Churchwell, D. Doerge
- Biology, ChemistryChemical Research in Toxicology
- 12 September 2003
DNA adduct formation from AA treatment in adult mice showed a supralinear dose-response relationship, consistent with saturation of oxidative metabolism at higher doses, which increases the understanding of the mutagenic potential of GA and provides further evidence for a genotoxic mechanism in AA carcinogenesis.
High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of benzo[a]pyrene-DNA adducts.
The HPLC-ES-MS/MS method is suitable to assess the contribution of BP to DNA damage caused by exposures to polycyclic aromatic hydrocarbon (PAH) mixtures and suggests that dG-BPDE may contribute only a small fraction of the total DNA adducts detected by otherDNA adduct methodologies in individuals exposed to PAHs.
Pyrrolizidine alkaloid-derived DNA adducts as a common biological biomarker of pyrrolizidine alkaloid-induced tumorigenicity.
This first finding that a set of exogenous DNA adducts are commonly formed from a series of tumorigenic xenobiotics is found is a common biological biomarker of pyrrolizidine alkaloid-induced liver tumor formation.
Tumorigenicity of chloral hydrate, trichloroacetic acid, trichloroethanol, malondialdehyde, 4-hydroxy-2-nonenal, crotonaldehyde, and acrolein in the B6C3F(1) neonatal mouse.
DNA adducts and carcinogenicity of nitro-polycyclic aromatic hydrocarbons.
- P. Fu, D. Herreno-saenz, F. E. Evans
- Chemistry, BiologyEnvironmental health perspectives
- 1 August 1994
We have been interested in the structure-activity relationships of nitro-polycyclic aromatic hydrocarbons (nitro-PAHs), and have focused on the correlation of structural and electronic features with…
Effect of the nitro group conformation on the rat liver microsomal metabolism and bacterial mutagenicity of 2- and 9-nitroanthracene.
- P. Fu, R. Heflich, L. S. Von tungeln, D. Yang, E. K. Fifer, F. Beland
- Biology, ChemistryCarcinogenesis
- 1 November 1986
Results suggest that 2-NA can be metabolized to mutagenic products by nitroreduction and ring-oxidation followed by nit mirroreduction, but not nitrored reduction followed by ring- oxidation.
Comparative carcinogenicity of 4-aminobiphenyl and the food pyrolysates, Glu-P-1, IQ, PhIP, and MeIQx in the neonatal B6C3F1 male mouse.
Immunochemical, 32P-postlabeling, and GC/MS detection of 4-aminobiphenyl-DNA adducts in human peripheral lung in relation to metabolic activation pathways involving pulmonary N-oxidation,…
Highly sensitive chemiluminescence immunoassay for benzo[a]pyrene-DNA adducts: validation by comparison with other methods, and use in human biomonitoring.
The BPDE-DNA CIA was developed and validated to study the formation of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in human tissues and validated in MCL-5 cells exposed to 4 micro M BP for 24 h, where nuclear and mitochondrial DNA adduct levels were associated with an increase in DNA tail length measured by the Comet assay.