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Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells.
- J. M. de Murcia, C. Niedergang, G. de Murcia
- BiologyProceedings of the National Academy of Sciences…
- 8 July 1997
Results demonstrate that PARP is a survival factor playing an essential and positive role during DNA damage recovery, and inactivated both alleles by gene targeting in mice.
Chromosomal evolution in Primates: Tentative phylogeny from Microcebus murinus (Prosimian) to man
- B. Dutrillaux
- BiologyHuman Genetics
- 10 May 1979
The karyotypes of more than 60 species of Primates are studied and compared, with the use of almost all existing banding techniques, and a fairly precise genealogy of many Primates is proposed, giving the positions of the Catarrhines, the Platyrrhines, and the Prosimians is proposed.
Common fragile sites: mechanisms of instability revisited.
`Side Population' cells in adult mouse testis express Bcrp1 gene and are enriched in spermatogonia and germinal stem cells
In vivo repopulation assay clearly establishes that testis `Side Population' in adult mice is highly enriched in male germ stem cells, and indicates that germinal ` side Population' contains spermatogonial cells.
NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines.
The isolation and characterization of NSD3, the third member of a gene family including Nsd1 and NSD2, is described, which maps to chromosome band 8p12 and is amplified in several tumor cell lines and primary breast carcinomas.
Common fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites hosting large genes.
The 11q;22q translocation: A European collaborative analysis of 43 cases
A segregation analysis revealed that in families ascertained through probands with unbalanced karyotypes there was a ratio of carriers to normal (all karyotyped) 54:55, not a significant difference, which suggests that heterozygosity for the translocation reduces fertility in males.
Establishment and characterisation of a new tumorigenic cell line with a normal karyotype derived from a human breast adenocarcinoma.
Cytogenetic analysis of the cells from the tumour induced by CAL51 in the nude mouse confirmed the normality and the stability of the karyotype, and may be more informative than cell lines with aberrant karyotypes for investigating essential genetic differences between normal and malignant mammary gland cells.
Sequence of DNA replication in 277 R- and Q-bands of human chromosomes using a BrdU treatment
The heterochromatin of chromosomes 1, 16 and Y and of the short arms of the acrocentrics could contain two types of DNA which replicate at different times.
Reconstruction of the ancestral karyotype of eutherian mammals
The ancestral karyotype of eutherian mammals was tentatively reconstructed using the parsimony principle and compared chromosome banding with all ZOO-FISH data from literature or studied by us, this reconstruction can be proposed with only limited uncertainties.