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chlorothricin

 
National Institutes of Health

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Aminoglycosides

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2016
2016
Coordinative Modulation of Chlorothricin Biosynthesis by Binding of the Glycosylated Intermediates and End Product to a Responsive Regulator ChlF1*
Chlorothricin, isolated from Streptomyces antibioticus, is a parent member of spirotetronate family of antibiotics that have long… Expand
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2011
2011
Abyssomicin Biosynthesis: Formation of an Unusual Polyketide, Antibiotic-Feeding Studies and Genetic Analysis
Abyssomicin C, produced by the marine actinomycete Verrucosispora maris AB-18-032, is active against Gram-positive bacteria… Expand
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2008
2008
Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.
Tetrocarcin A (TCA), produced by Micromonospora chalcea NRRL 11289, is a spirotetronate antibiotic with potent antitumor activity… Expand
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2007
2007
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.
The antibiotic kijanimicin produced by the actinomycete Actinomadura kijaniata has a broad spectrum of bioactivities as well as a… Expand
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2006
2006
Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.
The biosynthetic gene cluster for chlorothricin (CHL) was localized to a 122 kb contiguous DNA from Streptomyces antibioticus DSM… Expand
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2006
2006
Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase.
Unusual polyketide synthases (PKSs), that are structurally type I but act in an iterative manner for aromatic polyketide… Expand
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1986
1986
Further studies on the biosynthesis of chlorothricin.
Feeding experiments with [U-13C3]- and (2R)-[1-2H2]glycerol showed that glycerol is incorporated intact into carbon atoms 22, 23… Expand
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1981
1981
Biosynthesis of the macrolide antibiotic chlorothricin.
Feeding experiments with 13C-labeled precursors followed by 13C NMR analysis of the antibiotic and its aglycon have established a… Expand
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1978
1978
Biosynthesis of the macrolide antibiotic chlorothricin: basic building blocks.
The biosynthesis of chlorothricin (I), a macrolide antibiotic isolated from Streptomyces antibioticus Tü 99, has been studied by… Expand
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1972
1972
Interaction of antibiotics with membranes: chlorothricin.
The mode of interaction of the antibiotic chlorothricin with cell membranes has been studied using lecithin-water dispersions as… Expand
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