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chlorothricin

National Institutes of Health

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Aminoglycosides

Papers overview

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Review
2014
Review
2014
Spirotetronate Polyketides as Leads in Drug Discovery
The discovery of chlorothricin (1) defined a new family of microbial metabolites with potent antitumor antibiotic properties… 
Highly Cited
2011
Highly Cited
2011
Abyssomicin Biosynthesis: Formation of an Unusual Polyketide, Antibiotic-Feeding Studies and Genetic Analysis
Abyssomicin C, produced by the marine actinomycete Verrucosispora maris AB-18-032, is active against Gram-positive bacteria… 
2010
2010
Insights into bacterial 6-methylsalicylic acid synthase and its engineering to orsellinic acid synthase for spirotetronate generation.
Highly Cited
2008
Highly Cited
2008
Cloning and Characterization of the Tetrocarcin A Gene Cluster from Micromonospora chalcea NRRL 11289 Reveals a Highly Conserved Strategy for Tetronate Biosynthesis in Spirotetronate Antibiotics
ABSTRACT Tetrocarcin A (TCA), produced by Micromonospora chalcea NRRL 11289, is a spirotetronate antibiotic with potent antitumor… 
Highly Cited
2007
Highly Cited
2007
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.
The antibiotic kijanimicin produced by the actinomycete Actinomadura kijaniata has a broad spectrum of bioactivities as well as a… 
2006
2006
Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase.
  • L. ShaoX. Qu Wen Liu
  • Biochemical and Biophysical Research…
  • 2006
  • Corpus ID: 24181974
Highly Cited
2006
Highly Cited
2006
Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.
1986
1986
Further studies on the biosynthesis of chlorothricin.
Feeding experiments with [U-13C3]- and (2R)-[1-2H2]glycerol showed that glycerol is incorporated intact into carbon atoms 22, 23… 
1981
1981
Biosynthesis of the macrolide antibiotic chlorothricin.
Feeding experiments with 13C-labeled precursors followed by 13C NMR analysis of the antibiotic and its aglycon have established a… 
1975
1975
Chlorothricin, and inhibitor of porcine-heart malate dehydrogenases, discriminating between the mitochondrial and cytoplasmic isoenzyme.
  • P. Schindler
  • European Journal of Biochemistry
  • 1975
  • Corpus ID: 2948188
The macrolide-type antibiotic chlorothricin was found to inhibit both the mitochondrial and the cytoplasmic form of pig heart… 
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