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caspase-7

Known as: MCH3, Protease Mch-3, Apoptotic, CMH-1 
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 3 and CASPASE 10. Several… 
National Institutes of Health

Related topics

Related topics

33 relations
Alzheimer's Disease Pathway KEGGApoptosisCASP2 protein, humanCASP4 protein, human

Broader (1)

Cysteine Endopeptidases

Narrower (1)

Procaspase 7

Papers overview

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Highly Cited
2011
Highly Cited
2011
Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy.
The outcome of producing apoptotic defects in cancer cells is the primary obstacle that limits the therapeutic… 
Highly Cited
2009
Highly Cited
2009
Assessment of Apoptosis by Immunohistochemistry to Active Caspase-3, Active Caspase-7, or Cleaved PARP in Monolayer Cells and Spheroid and Subcutaneous Xenografts of Human Carcinoma
Immunohistochemistry to active caspase-3, recently recommended for apoptosis detection, is inappropriate to detect apoptosis… 
Highly Cited
2009
Highly Cited
2009
Fucoidan induces apoptosis through activation of caspase-8 on human breast cancer MCF-7 cells.
Fucoidan is an active component of seaweed that has been shown to inhibit proliferation and induce apoptotic cell death in… 
Highly Cited
2003
Highly Cited
2003
Endoplasmic Reticulum Chaperone Protein GRP78 Protects Cells from Apoptosis Induced by Topoisomerase Inhibitors
A large number of correlative studies have established that the activation of the unfolded protein response (UPR) alters the cell… 
Highly Cited
2003
Highly Cited
2003
Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor–κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of…
Because of the central role of the transcription factor nuclear factor–κB (NF-κB) in cell survival and proliferation in human… 
Highly Cited
2002
Highly Cited
2002
Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78
Highly Cited
2001
Highly Cited
2001
Crystal Structure of a Procaspase-7 Zymogen Mechanisms of Activation and Substrate Binding
Highly Cited
2000
Highly Cited
2000
The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7.
The inhibitor of apoptosis, cIAP2, contains a putative Ring finger motif at the C terminus. Using in vitro ubiquitination assays… 
Highly Cited
1997
Highly Cited
1997
The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases
Highly Cited
1996
Highly Cited
1996
Identification and Characterization of CPP32/Mch2 Homolog 1, a Novel Cysteine Protease Similar to CPP32 (*)
We have identified and characterized a novel cysteine protease named CMH-1 that is a new member of the interleukin 1β converting… 
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