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The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis
In vivo, the RING finger of DIAP1 is essential for the regulation of apoptosis induced by Rpr, Hid and Dronc, and the data suggest that IAPs suppress apoptosis by binding to and targeting caspases for ubiquitination.
Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis
It is shown that Drosophila IAP 1 (DIAP1) is degraded by the 'N-end rule' pathway and that this process is indispensable for regulating apoptosis, and suggested that DIAP1 instability, mediated through caspase activity and subsequent exposure of the N- end rule pathway, is essential for suppression of apoptosis.
IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms
It is shown that IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms, and it is demonstrated that the mammalian IAP c-IAP1 interacts with caspase-7 in an exclusively IBM-dependent, but active site pocket-independent, manner that is mechanistically similar to DIAP1.
Inactivation of effector caspases through nondegradative polyubiquitylation.
Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases.
Two-color Photoactivatable Probe for Selective Tracking of Proteins and Cells*
- A. Welman, A. Serrels, V. Brunton, M. Ditzel, M. Frame
- BiologyThe Journal of Biological Chemistry
- 5 February 2010
It is shown that zyxin is continuously and rapidly recruited from the cytosol into established focal adhesions and can also move rapidly within a given focal adhesion and “hop” between adjacent focalAdhesions, emphasizing the dynamic nature of proteins within these structures.
The antiapoptotic activity of insect IAPs requires activation by an evolutionarily conserved mechanism
It is demonstrated that the antiapoptotic activity of diverse insect IAPs is activated by effector caspase, providing the cell with a sensitive strategy to monitor and neutralise active caspases.
IAP degradation: decisive blow or altruistic sacrifice?
Regulation of hedgehog Ligand Expression by the N-End Rule Ubiquitin-Protein Ligase Hyperplastic Discs and the Drosophila GSK3β Homologue, Shaggy
Drosophila-based findings highlight an apical role for Hyd and Sgg in initiating Hedgehog signalling, which could also be evolutionarily conserved in mammals.
A Prickly Subject: Apoptotic Regulation by Hedgehog Morphogens
- M. Ditzel
- 14 April 2011
This review aims to highlight the apoptotic regulatory mechanisms utilised by the Hedgehog (HH) morphogen pathway with particular emphasis on a novel Caspase-9 activating complex and the utilisation of a pro-apoptotic autocrine-signalling loop.