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carebastine

Known as: Benzeneacetic acid, 4-(4-(4-(diphenylmethoxy)-1-piperidinyl)-1-oxobutyl)-alpha,alpha-dimethyl- 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (4)

Anti-Asthmatic AgentsButyrophenonesHistamine H1 AntagonistsPiperidines

Papers overview

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2013
2013
Comparison of catalytic properties of cytochromes P450 3A4 and 3A5 by molecular docking simulation.
To investigate the reported differences in catalytic activities of cytochromes P450 (CYP or P450) 3A4 and 3A5, molecular docking… 
2011
2011
Myocardial pharmacokinetics of ebastine, a substrate for cytochrome P450 2J, in rat isolated heart
BACKGROUND AND PURPOSE It is well established that cytochrome P450 2J (CYP2J) enzymes are expressed preferentially in the heart… 
2010
2010
Application of a rapid and selective method for the simultaneous determination of carebastine and pseudoephedrine in human plasma by liquid chromatography-electrospray mass spectrometry for…
We describe a simple, rapid and sensitive high-performance liquid chromatography-electrospray ionization tandem mass… 
2006
2006
The effect of CYP2J2, CYP3A4, CYP3A5 and the MDR1 polymorphisms and gender on the urinary excretion of the metabolites of the H-receptor antihistamine ebastine: a pilot study.
AIMS To determine the effect of gender and the genetic polymorphisms of CYP2J2, CYP3A4, CYP3A5 and MDR1 on the urinary excretion… 
2001
2001
Regulatory effect of histamine H1 receptor antagonist on the expression of messenger RNA encoding CC chemokines in the human nasal mucosa.
BACKGROUND Allergic rhinitis is characterized by tissue accumulation of inflammatory cells. CC chemokines, including monocyte… 
2001
2001
Effect of age and gender on the pharmacokinetics of ebastine after single and repeated dosing in healthy subjects.
OBJECTIVES Ebastine is a potent and selective H1-receptor antagonist indicated for allergic rhinitis which undergoes extensive… 
Review
1999
Review
1999
Cardiac Effects of Ebastine and Other Antihistamines in Humans
The electrocardiographic effects of ebastine and its active metabolite, carebastine, have been studied alone and in relevant drug… 
1999
1999
Consistency and efficacy of cetirizine (10 mg) versus ebastine (20 mg) at 4 h on skin reactivity
AbstractObjective: We compared the consistency and efficacy of the two antihistamines, cetirizine (10 mg) and ebastine (20 mg) on… 
1998
1998
Comparative study of different weighting methods in non-linear regression analysis: implications in the parametrization of carebastine after intravenous administration in healthy volunteers.
The influence of different weighting methods in non-linear regression analysis was evaluated in the pharmacokinetics of… 
1994
1994
Comparative pharmacokinetics of the histamine H1-receptor antagonist ebastine and its active metabolite carebastine in rats, guinea pigs, dogs and monkeys.
The pharmacokinetics of ebastine (CAS 90729-43-4), a new histamine H1-receptor antagonist, was investigated in rats, guinea pigs… 
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