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carebastine

Known as: Benzeneacetic acid, 4-(4-(4-(diphenylmethoxy)-1-piperidinyl)-1-oxobutyl)-alpha,alpha-dimethyl- 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2014
02419882014

Related topics

Related topics

4 relations

Broader (4)

Anti-Asthmatic AgentsButyrophenonesHistamine H1 AntagonistsPiperidines

Related mentions per year

Related mentions per year

1945-2018
19401960198020002020
carebastine
Histamine H1 Antagonists
Anti-Asthmatic Agents
Butyrophenones
Piperidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Anti-angiogenic activity of carebastine: a plausible mechanism affecting airway remodelling.
Ebastine is a well-known selective second-generation histamine H(1) receptor antagonist, which is used for seasonal and perennial… (More)
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2006
2006
Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A.
Ebastine undergoes extensive metabolism to form desalkylebastine and hydroxyebastine. Hydroxyebastine is subsequently metabolized… (More)
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2004
2004
Microbial oxidation of terfenadine and ebastine into fexofenadine and carebastine.
The oxidation of tert-butyl-phenyl group of title compounds by some microorganisms was studied. We have optimized the conditions… (More)
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2001
2001
Simultaneous determination of the histamine H1-receptor antagonist ebastine and its two metabolites, carebastine and hydroxyebastine, in human plasma using high-performance liquid chromatography.
Ebastine (CAS 90729-43-4) is an antiallergic agent which selectively and potently blocks histamine H1-receptors in vivo. A simple… (More)
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2001
2001
Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a…
AIMS Sedation induced by antihistamines is widely recognized to be caused by their penetration through the blood-brain-barrier… (More)
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2000
2000
Blood-brain barrier transport of H1-antagonist ebastine and its metabolite carebastine.
The transport mechanism of the non-sedative H1-antagonist ebastine and its first-pass carboxylic acid metabolite carebastine at… (More)
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Review
2000
Review
2000
Carebastine Almirall Prodesfarma.
  • P Kingham
  • Current opinion in investigational drugs
  • 2000
Carebastine, a histamine H1 antagonist, is under development by Almirall Prodesfarma for the potential treatment of allergic… (More)
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1994
1994
Pharmacokinetics of the H1-receptor antagonist ebastine and its active metabolite carebastine in healthy subjects.
Pharmacokinetics of ebastine (CAS 90729-43-4), a histamine H1-receptor antagonist, was evaluated in healthy male volunteers. The… (More)
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1994
1994
Comparative pharmacokinetics of the histamine H1-receptor antagonist ebastine and its active metabolite carebastine in rats, guinea pigs, dogs and monkeys.
The pharmacokinetics of ebastine (CAS 90729-43-4), a new histamine H1-receptor antagonist, was investigated in rats, guinea pigs… (More)
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1993
1993
Cimetidine does not influence the metabolism of the H1-receptor antagonist ebastine to its active metabolite carebastine.
Ebastine is an H1-receptor antagonist with a relative lack of sedating properties. It is almost completely converted to… (More)
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