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carebastine

Known as: Benzeneacetic acid, 4-(4-(4-(diphenylmethoxy)-1-piperidinyl)-1-oxobutyl)-alpha,alpha-dimethyl- 
 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (4)

Anti-Asthmatic AgentsButyrophenonesHistamine H1 AntagonistsPiperidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
The effect of H1 antagonists carebastine and olopatadine on histamine induced expression of CC chemokines in cultured human nasal epithelial cells.
BACKGROUND CC chemokines have been shown to play an important role in inducing selective recruitment of inflammatory cells into… Expand
Highly Cited
2006
Highly Cited
2006
Characterization of Ebastine, Hydroxyebastine, and Carebastine Metabolism by Human Liver Microsomes and Expressed Cytochrome P450 Enzymes: Major Roles for CYP2J2 and CYP3A
Ebastine undergoes extensive metabolism to form desalkylebastine and hydroxyebastine. Hydroxyebastine is subsequently metabolized… Expand
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Highly Cited
2001
Highly Cited
2001
Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a…
AIMS Sedation induced by antihistamines is widely recognized to be caused by their penetration through the blood-brain-barrier… Expand
2001
2001
Simultaneous determination of the histamine H1-receptor antagonist ebastine and its two metabolites, carebastine and hydroxyebastine, in human plasma using high-performance liquid chromatography.
Ebastine (CAS 90729-43-4) is an antiallergic agent which selectively and potently blocks histamine H1-receptors in vivo. A simple… Expand
Review
2000
Review
2000
Ebastine: an update of its use in allergic disorders.
UNLABELLED Ebastine is a second-generation antihistamine which undergoes transformation to its active metabolite, carebastine… Expand
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2000
2000
Blood-Brain Barrier Transport of H1-Antagonist Ebastine and its Metabolite Carebastine
Abstract The transport mechanism of the non-sedative Hl-antagonist ebastine and its first-pass car-boxylic acid metabolite… Expand
1998
1998
N-Dealkylation and hydroxylation of ebastine by human liver cytochrome P450.
Ebastine [4'-tert-butyl-4-[4-(diphenylmethoxy)piperidino]butyro phe- none] is a new-generation, nonsedative, H1 antihistamine… Expand
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Highly Cited
1996
Highly Cited
1996
Comparative analysis of the cardiotoxicity proclivities of second generation antihistamines in an experimental model predictive of adverse clinical ECG effects.
Terfenadine and astemizole belong to the second generation histamine H1 antagonists and are widely prescribed for allergic and… Expand
1994
1994
Pharmacokinetics of the H1-receptor antagonist ebastine and its active metabolite carebastine in healthy subjects.
Pharmacokinetics of ebastine (CAS 90729-43-4), a histamine H1-receptor antagonist, was evaluated in healthy male volunteers. The… Expand
Highly Cited
1988
Highly Cited
1988
The pharmacokinetics, antihistamine and concentration-effect relationship of ebastine in healthy subjects.
1. The kinetics and effects of ebastine 10 and 50 mg were studied after oral dosing in healthy subjects. 2. The parent drug was… Expand
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