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carbovir

Known as: (+ -)-Carbovir, 2',3'-didehydro-2',3'-dideoxyguanosine 
A nucleoside reverse transcriptase inhibitor analog of guanosine. Carbovir decreases HIV viral loads, retards or prevents the damage to the immune… Expand
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Anti-HIV AgentsDideoxynucleosides

Narrower (1)

NSC 614846

Papers overview

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2014
2014
Structural and energetic properties of the potential HIV-1 reverse transcriptase inhibitors d4A and d4G: a comprehensive theoretical investigation.
A comprehensive quantum-chemical investigation of the conformational landscapes of two nucleoside HIV-1 reverse transcriptase… Expand
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2011
2011
Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase.
OBJECTIVE To provide a molecular mechanism that explains the association of the antiretroviral guanosine analogue, abacavir, with… Expand
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Highly Cited
2007
Highly Cited
2007
Mitochondrial toxicity of tenofovir, emtricitabine and abacavir alone and in combination with additional nucleoside reverse transcriptase inhibitors.
BACKGROUND Some nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) combinations cause additive or synergistic… Expand
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2005
2005
A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT.
OBJECTIVE To determine the mechanisms of resistance of K65R mutant reverse transcriptase (RT) to the currently approved… Expand
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2003
2003
Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs.
Although antiviral nucleoside analog therapy successfully delays progression of HIV infection to AIDS, these drugs cause… Expand
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Highly Cited
2002
Highly Cited
2002
Molecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R+M184V and their effects on enzyme function and viral replication capacity.
Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) resistance mutations K65R and M184V result in changes in… Expand
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Highly Cited
2001
Highly Cited
2001
Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase*
To examine the role of the mitochondrial polymerase (Pol γ) in clinically observed toxicity of nucleoside analogs used to treat… Expand
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2001
2001
Antiviral Activity of Cyclosaligenyl Prodrugs of Acyclovir, Carbovir and Abacavir
The cyclosaligenyl (cycloSal) derivatives of the monophosphates of three acyclic or carbocyclic guanosine analogues, for example… Expand
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1989
1989
Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells.
2',3'-Dideoxyinosine (ddlno) is a potent and selective inhibitor of human immunodeficiency virus in human lymphoid cells and… Expand
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1988
1988
Potent and selective activity of a new carbocyclic nucleoside analog (carbovir: NSC 614846) against human immunodeficiency virus in vitro.
Carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine (Carbovir: NSC 614846), a novel nucleoside analog, emerged as a potent and… Expand
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