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carbovir

Known as: (+ -)-Carbovir, 2',3'-didehydro-2',3'-dideoxyguanosine 
A nucleoside reverse transcriptase inhibitor analog of guanosine. Carbovir decreases HIV viral loads, retards or prevents the damage to the immune… Expand
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Anti-HIV AgentsDideoxynucleosides

Narrower (1)

NSC 614846

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2002
2002
Novel Use of a Guanosine Prodrug Approach To Convert 2',3'-Didehydro-2',3'-Dideoxyguanosine into a Viable Antiviral Agent
ABSTRACT Transient kinetic studies with human immunodeficiency virus (HIV) type 1 reverse transcriptase suggest that nucleotide… Expand
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Highly Cited
2002
Highly Cited
2002
Molecular Mechanisms of Resistance to Human Immunodeficiency Virus Type 1 with Reverse Transcriptase Mutations K65R and K65R+M184V and Their Effects on Enzyme Function and Viral Replication Capacity
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) resistance mutations K65R and M184V result in… Expand
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Highly Cited
2001
Highly Cited
2001
Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase*
  • Allison A. Johnson, A. Ray, +4 authors Kenneth A. Johnson
  • The Journal of Biological Chemistry
  • 2001
    • Corpus ID: 275016
To examine the role of the mitochondrial polymerase (Pol γ) in clinically observed toxicity of nucleoside analogs used to treat… Expand
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Highly Cited
1991
Highly Cited
1991
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases alpha, beta, and gamma by the 5'-triphosphates of carbovir, 3'-azido-3'-deoxythymidine…
Carbovir (the carbocyclic analog of 2'-3'-didehydro-2',3'-dideoxyguanosine) is a potent inhibitor of human immunodeficiency virus… Expand
Highly Cited
1990
Highly Cited
1990
Synthesis and anti-HIV activity of carbocyclic 2',3'-didehydro-2',3'-dideoxy 2,6-disubstituted purine nucleosides.
(+-)-cis-[4-[(2,5-Diamino-6-chloropyrimidinyl)amino]-2- cyclopentenyl]carbinol (5a) was synthesized from 2-amino-4,6… Expand
Highly Cited
1990
Highly Cited
1990
Resolution of racemic carbovir and selective inhibition of human immunodeficiency virus by the (-) enantiomer.
(+-) Carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine (Carbovir; NSC 614846) is an antiretroviral agent which is undergoing… Expand
1990
1990
Metabolism of the carbocyclic nucleoside analogue carbovir, an inhibitor of human immunodeficiency virus, in human lymphoid cells.
Carbovir (CBV) is a highly selective carbocyclic nucleoside inhibitor of HIV replication in human lymphocytes and is potentially… Expand
Highly Cited
1989
Highly Cited
1989
Comparison of the effect of Carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases.
Carbocylic 2',3'-didehydro-2',3'-dideoxyguanosine (Carbovir; NSC 614846) is an antiretroviral agent which may be useful in the… Expand
Highly Cited
1989
Highly Cited
1989
Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells.
2',3'-Dideoxyinosine (ddlno) is a potent and selective inhibitor of human immunodeficiency virus in human lymphoid cells and… Expand
Highly Cited
1988
Highly Cited
1988
Potent and selective activity of a new carbocyclic nucleoside analog (carbovir: NSC 614846) against human immunodeficiency virus in vitro.
Carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine (Carbovir: NSC 614846), a novel nucleoside analog, emerged as a potent and… Expand
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