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carbovir
Known as:
(+ -)-Carbovir
, 2',3'-didehydro-2',3'-dideoxyguanosine
A nucleoside reverse transcriptase inhibitor analog of guanosine. Carbovir decreases HIV viral loads, retards or prevents the damage to the immune…
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National Institutes of Health
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Related topics
Related topics
3 relations
Broader (2)
Anti-HIV Agents
Dideoxynucleosides
Narrower (1)
NSC 614846
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT
K. White
,
N. Margot
,
+7 authors
Michael D. Miller
AIDS (London)
2005
Corpus ID: 2137967
Objective:To determine the mechanisms of resistance of K65R mutant reverse transcriptase (RT) to the currently approved…
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2001
2001
A new stereoselective route to the carbocyclic nucleoside cyclobut-A
J. Panda
,
Sarita Ghosh
,
Subrata K. Ghosh
2001
Corpus ID: 53509470
A new synthesis of cyclobut-A, a carbocyclic nucleoside analogue of oxetanocin is described. The key step involves a…
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2000
2000
A novel, one-pot ring expansion of cyclobutanones. Syntheses of carbovir and aristeromycin.
Brian Brown
,
L. Hegedus
Journal of Organic Chemistry
2000
Corpus ID: 19288928
A novel, one-pot ring-expansion procedure was developed using Me3S(O)I, NaH, and Sc(OTf)3. The scope and limitations were briefly…
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1999
1999
Stereoselective Synthesis of 4'-α-Alkylcarbovir Derivatives Based on an Asymmetric Synthesis or Chemoenzymatic Procedure
Keisuke Kato
,
H. Suzuki
,
+4 authors
H. Akita
1999
Corpus ID: 59145128
Stereoselective synthesis of 4'-α-alkylcarbovir derivatives 4 was described based on asymmetric synthesis or a chemoenzymatic…
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1994
1994
Enzyme-catalysed kinetic resolution of 4-endo-hydroxy-2-oxabicyclo[3.3.0]oct-7-en-3-one and employment of the pure enantiomers for the synthesis of anti-viral and hypocholestemic agents.
R. Mackeith
,
R. Mccague
,
H. Olivo
,
S. Roberts
,
S. Taylor
,
H. Xiong
Bioorganic & Medicinal Chemistry
1994
Corpus ID: 36233840
1992
1992
DNA chain termination activity and inhibition of human immunodeficiency virus reverse transcriptase by carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine triphosphate.
D. Orr
,
H. T. Figueiredo
,
C. Mo
,
C. Penn
,
J. Cameron
Journal of Biological Chemistry
1992
Corpus ID: 21013179
Highly Cited
1992
Highly Cited
1992
Synthesis and anti-HIV activity of 9-[c-4,t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H-adenine.
N. Katagiri
,
M. Nomura
,
H. Satō
,
C. Kaneko
,
K. Yusa
,
T. Tsuruo
Journal of Medicinal Chemistry
1992
Corpus ID: 45109467
The synthesis and in vitro anti-HIV activity of two new racemic nucleoside analogues are described; namely, 9-[c-4,t-5-bis…
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1990
1990
Metabolism of the carbocyclic nucleoside analogue carbovir, an inhibitor of human immunodeficiency virus, in human lymphoid cells.
L. L. Bondoc
,
W. M. Shannon
,
J. Secrist
,
R. Vince
,
A. Fridland
Biochemistry
1990
Corpus ID: 29912269
Carbovir (CBV) is a highly selective carbocyclic nucleoside inhibitor of HIV replication in human lymphocytes and is potentially…
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Review
1990
Review
1990
Chromatographic methods for the bioanalysis of antiviral agents.
C. Riley
,
J. M. Ault
,
N. Klutman
Journal of Chromatography A
1990
Corpus ID: 45835824
1990
1990
Differential toxicity of carbovir and AZT to human bone marrow hematopoietic progenitor cells in vitro.
J. Kurtzberg
,
S. Carter
Experimental Hematology
1990
Corpus ID: 31649742
We have studied the in vitro effects of carbovir as compared to 3'-azido-3'-deoxythymidine (AZT) on the growth of clonal bone…
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