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carbovir

Known as: (+ -)-Carbovir, 2',3'-didehydro-2',3'-dideoxyguanosine 
A nucleoside reverse transcriptase inhibitor analog of guanosine. Carbovir decreases HIV viral loads, retards or prevents the damage to the immune… Expand
National Institutes of Health

Papers overview

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2014
2014
A comprehensive quantum-chemical investigation of the conformational landscapes of two nucleoside HIV-1 reverse transcriptase… Expand
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2011
2011
OBJECTIVE To provide a molecular mechanism that explains the association of the antiretroviral guanosine analogue, abacavir, with… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Some nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) combinations cause additive or synergistic… Expand
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2005
2005
OBJECTIVE To determine the mechanisms of resistance of K65R mutant reverse transcriptase (RT) to the currently approved… Expand
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2003
2003
Although antiviral nucleoside analog therapy successfully delays progression of HIV infection to AIDS, these drugs cause… Expand
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Highly Cited
2002
Highly Cited
2002
Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) resistance mutations K65R and M184V result in changes in… Expand
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Highly Cited
2001
Highly Cited
2001
To examine the role of the mitochondrial polymerase (Pol γ) in clinically observed toxicity of nucleoside analogs used to treat… Expand
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2001
2001
The cyclosaligenyl (cycloSal) derivatives of the monophosphates of three acyclic or carbocyclic guanosine analogues, for example… Expand
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1989
1989
2',3'-Dideoxyinosine (ddlno) is a potent and selective inhibitor of human immunodeficiency virus in human lymphoid cells and… Expand
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1988
1988
Carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine (Carbovir: NSC 614846), a novel nucleoside analog, emerged as a potent and… Expand
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