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carbovir
Known as:
(+ -)-Carbovir
, 2',3'-didehydro-2',3'-dideoxyguanosine
A nucleoside reverse transcriptase inhibitor analog of guanosine. Carbovir decreases HIV viral loads, retards or prevents the damage to the immune…
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National Institutes of Health
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Related topics
Related topics
3 relations
Broader (2)
Anti-HIV Agents
Dideoxynucleosides
Narrower (1)
NSC 614846
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2020
Highly Cited
2020
A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19
S. Jockusch
,
C. Tao
,
+6 authors
J. Ju
Antiviral Research
2020
Corpus ID: 219722080
Highly Cited
2005
Highly Cited
2005
Simultaneous analysis of several antiretroviral nucleosides in rat-plasma by high-performance liquid chromatography with UV using acetic acid/hydroxylamine buffer Test of this new volatile medium-pH…
Vincent Bezy
,
P. Morin
,
P. Couerbe
,
G. Leleu
,
L. Agrofoglio
Journal of chromatography. B, Analytical…
2005
Corpus ID: 29246381
Highly Cited
2003
Highly Cited
2003
Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs.
Susan E. Lim
,
M. V. Ponamarev
,
M. Longley
,
W. Copeland
Journal of Molecular Biology
2003
Corpus ID: 37532313
Review
2003
Review
2003
Toxicity of nucleoside analogues used to treat AIDS and the selectivity of the mitochondrial DNA polymerase.
Harold R Lee
,
Jeremiah W. Hanes
,
Kenneth A. Johnson
Biochemistry
2003
Corpus ID: 22972322
Incorporation of nucleoside analogues by the mitochondrial DNA polymerase has been implicated as the primary cause underlying…
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2002
2002
Novel Use of a Guanosine Prodrug Approach To Convert 2',3'-Didehydro-2',3'-Dideoxyguanosine into a Viable Antiviral Agent
A. Ray
,
Zhenjun Yang
,
C. K. Chu
,
K. Anderson
Antimicrobial Agents and Chemotherapy
2002
Corpus ID: 28479350
ABSTRACT Transient kinetic studies with human immunodeficiency virus (HIV) type 1 reverse transcriptase suggest that nucleotide…
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Highly Cited
2002
Highly Cited
2002
Molecular Mechanisms of Resistance to Human Immunodeficiency Virus Type 1 with Reverse Transcriptase Mutations K65R and K65R+M184V and Their Effects on Enzyme Function and Viral Replication Capacity
K. White
,
N. Margot
,
T. Wrin
,
C. Petropoulos
,
M. Miller
,
L. Naeger
Antimicrobial Agents and Chemotherapy
2002
Corpus ID: 10402578
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) resistance mutations K65R and M184V result in…
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Highly Cited
2001
Highly Cited
2001
Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase*
Allison A. Johnson
,
A. Ray
,
+4 authors
Kenneth A. Johnson
Journal of Biological Chemistry
2001
Corpus ID: 275016
To examine the role of the mitochondrial polymerase (Pol γ) in clinically observed toxicity of nucleoside analogs used to treat…
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Highly Cited
1996
Highly Cited
1996
Reverse transcriptase inhibitors suppress telomerase function and induce senescence‐like processes in cultured mouse fibroblasts
Y. Yegorov
,
D. N. Chernov
,
Sergei S. Akimov
,
Nadezda L. Bolsheva
,
A. Krayevsky
,
A. Zelenin
FEBS Letters
1996
Corpus ID: 30654136
Highly Cited
1990
Highly Cited
1990
Synthesis and anti-HIV activity of carbocyclic 2',3'-didehydro-2',3'-dideoxy 2,6-disubstituted purine nucleosides.
R. Vince
,
M. Hua
Journal of Medicinal Chemistry
1990
Corpus ID: 33015270
(+-)-cis-[4-[(2,5-Diamino-6-chloropyrimidinyl)amino]-2- cyclopentenyl]carbinol (5a) was synthesized from 2-amino-4,6…
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Highly Cited
1989
Highly Cited
1989
Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells.
M. Johnson
,
A. Fridland
Molecular Pharmacology
1989
Corpus ID: 25259367
2',3'-Dideoxyinosine (ddlno) is a potent and selective inhibitor of human immunodeficiency virus in human lymphoid cells and…
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