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carbovir

Known as: (+ -)-Carbovir, 2',3'-didehydro-2',3'-dideoxyguanosine 
A nucleoside reverse transcriptase inhibitor analog of guanosine. Carbovir decreases HIV viral loads, retards or prevents the damage to the immune… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Anti-HIV AgentsDideoxynucleosides

Narrower (1)

NSC 614846

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2020
Highly Cited
2020
A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19
Highly Cited
2005
Highly Cited
2005
Simultaneous analysis of several antiretroviral nucleosides in rat-plasma by high-performance liquid chromatography with UV using acetic acid/hydroxylamine buffer Test of this new volatile medium-pH…
Highly Cited
2003
Highly Cited
2003
Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs.
Review
2003
Review
2003
Toxicity of nucleoside analogues used to treat AIDS and the selectivity of the mitochondrial DNA polymerase.
Incorporation of nucleoside analogues by the mitochondrial DNA polymerase has been implicated as the primary cause underlying… 
2002
2002
Novel Use of a Guanosine Prodrug Approach To Convert 2',3'-Didehydro-2',3'-Dideoxyguanosine into a Viable Antiviral Agent
ABSTRACT Transient kinetic studies with human immunodeficiency virus (HIV) type 1 reverse transcriptase suggest that nucleotide… 
Highly Cited
2002
Highly Cited
2002
Molecular Mechanisms of Resistance to Human Immunodeficiency Virus Type 1 with Reverse Transcriptase Mutations K65R and K65R+M184V and Their Effects on Enzyme Function and Viral Replication Capacity
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) resistance mutations K65R and M184V result in… 
Highly Cited
2001
Highly Cited
2001
Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase*
To examine the role of the mitochondrial polymerase (Pol γ) in clinically observed toxicity of nucleoside analogs used to treat… 
Highly Cited
1996
Highly Cited
1996
Reverse transcriptase inhibitors suppress telomerase function and induce senescence‐like processes in cultured mouse fibroblasts
Highly Cited
1990
Highly Cited
1990
Synthesis and anti-HIV activity of carbocyclic 2',3'-didehydro-2',3'-dideoxy 2,6-disubstituted purine nucleosides.
(+-)-cis-[4-[(2,5-Diamino-6-chloropyrimidinyl)amino]-2- cyclopentenyl]carbinol (5a) was synthesized from 2-amino-4,6… 
Highly Cited
1989
Highly Cited
1989
Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells.
2',3'-Dideoxyinosine (ddlno) is a potent and selective inhibitor of human immunodeficiency virus in human lymphoid cells and… 
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