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capravirine

Known as: (5-(3,5-dichlorophenyl)sulfanyl-4-propan-2-yl-1-(pyridin-4-ylmethyl)imidazol-2-yl)methyl aminoformate, 1H-Imidazole-2-methanol, 5-((3,5-dichlorophenyl)thio)-4-(1-methylethyl)-1-(4-pyridinylmethyl)-, carbamate (ester), 5-((3,5-Dichlorophenyl)thio)-4-isopropyl-1-(4-pyridylmethyl)imidazole-2-methanol Carbamate (ester) 
A non-nucleoside reverse transcriptase inhibitor. Capravirine shows antiviral activity against wild-type HIV as well as HIV strains with mutations in… 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (2)

AG-1549S 1153

Broader (2)

ImidazolesSulfur Compounds

Papers overview

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2012
2012
5α-reductase inhibitors, antiviral and anti-tumor activities of some steroidal cyanopyridinone derivatives.
2009
2009
Novel indazole non-nucleoside reverse transcriptase inhibitors using molecular hybridization based on crystallographic overlays.
A major problem associated with non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of HIV is their lack… 
Highly Cited
2007
Highly Cited
2007
Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs).
2006
2006
Arylthiopyrrole (AThP) Derivatives as Non‐Nucleoside HIV‐1 Reverse Transcriptase Inhibitors: Synthesis, Structure–Activity Relationships, and Docking Studies (Part 2)
Arylthio isopropyl pyridinylmethylpyrrolemethanols (AThPs) have been recently reported as a new class of human immunodeficiency… 
Review
2004
Review
2004
New non-nucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infections.
  • R. Pauwels
  • Current opinion in pharmacology (Print)
  • 2004
  • Corpus ID: 2718998
Review
2004
Review
2004
Current status of the non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1.
  • J. Balzarini
  • Current Topics in Medicinal Chemistry
  • 2004
  • Corpus ID: 42897031
Almost fifteen years ago, the first non-nucleoside reverse transcriptase (RT) inhibitor (NNRTI) lead compounds have been… 
2004
2004
Metabolism and excretion of capravirine, a new non-nucleoside reverse transcriptase inhibitor, alone and in combination with ritonavir in healthy volunteers.
Metabolism and disposition of capravirine, a new non-nucleoside reverse transcriptase inhibitor, were studied in healthy male… 
Review
2004
Review
2004
Non-nucleoside reverse transcriptase inhibitors (NNRTIs): past, present, and future.
  • E. De Clercq
  • Chemistry and Biodiversity
  • 2004
  • Corpus ID: 44604511
Non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) have become an inherent ingredient of the drug combination schemes… 
Review
2001
Review
2001
New developments in anti-HIV chemotherapy
  • E. De Clercq
  • Current Medicinal Chemistry
  • 2001
  • Corpus ID: 23439270
Abstract Virtually all the compounds that are currently used, or under advanced clinical trial, for the treatment of HIV… 
Highly Cited
2001
Highly Cited
2001
Antiviral drugs: current state of the art.
  • E. De Clercq
  • Journal of Clinical Virology
  • 2001
  • Corpus ID: 37871480
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