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capravirine

Known as: (5-(3,5-dichlorophenyl)sulfanyl-4-propan-2-yl-1-(pyridin-4-ylmethyl)imidazol-2-yl)methyl aminoformate, 1H-Imidazole-2-methanol, 5-((3,5-dichlorophenyl)thio)-4-(1-methylethyl)-1-(4-pyridinylmethyl)-, carbamate (ester), 5-((3,5-Dichlorophenyl)thio)-4-isopropyl-1-(4-pyridylmethyl)imidazole-2-methanol Carbamate (ester) 
A non-nucleoside reverse transcriptase inhibitor. Capravirine shows antiviral activity against wild-type HIV as well as HIV strains with mutations in… Expand
National Institutes of Health

Papers overview

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2006
2006
Capravirine (CPV; formerly AG1549 and S-1153) is a novel, nonnucleoside reverse transcriptase inhibitor (NNRTI) of human… Expand
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2005
2005
Different analogues of Capravirine (AG-1549) or S-1153 were prepared by synthesis of 2-(5-benzyl-4-isopropyl-1-methyl-2,3-dihydro… Expand
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2005
2005
Capravirine, a non-nucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus type 1, undergoes… Expand
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Review
2004
Review
2004
  • J. Balzarini
  • Current topics in medicinal chemistry
  • 2004
  • Corpus ID: 42897031
Almost fifteen years ago, the first non-nucleoside reverse transcriptase (RT) inhibitor (NNRTI) lead compounds have been… Expand
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2004
2004
Metabolism and disposition of capravirine, a new non-nucleoside reverse transcriptase inhibitor, were studied in healthy male… Expand
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Review
2004
Review
2004
  • R. Pauwels
  • Current opinion in pharmacology
  • 2004
  • Corpus ID: 2718998
Despite the availability of 20 approved anti-retroviral drugs for the treatment of HIV infection, there is still a need for new… Expand
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Review
2004
Review
2004
Non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) have become an inherent ingredient of the drug combination schemes… Expand
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2004
2004
Capravirine is a nonnucleoside reverse-transcriptase inhibitor (NNRTI) with a unique resistance profile. Although single… Expand
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Review
2001
Review
2001
  • E. De Clercq
  • Current medicinal chemistry
  • 2001
  • Corpus ID: 23439270
Virtually all the compounds that are currently used, or under advanced clinical trial, for the treatment of HIV infections… Expand
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Highly Cited
2001
Highly Cited
2001
  • E. De Clercq
  • Journal of clinical virology : the official…
  • 2001
  • Corpus ID: 37871480
The chemotherapy of virus infections has definitely come of age. There are now 15 antiviral agents that have been formally… Expand
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