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capravirine
Known as:
(5-(3,5-dichlorophenyl)sulfanyl-4-propan-2-yl-1-(pyridin-4-ylmethyl)imidazol-2-yl)methyl aminoformate
, 1H-Imidazole-2-methanol, 5-((3,5-dichlorophenyl)thio)-4-(1-methylethyl)-1-(4-pyridinylmethyl)-, carbamate (ester)
, 5-((3,5-Dichlorophenyl)thio)-4-isopropyl-1-(4-pyridylmethyl)imidazole-2-methanol Carbamate (ester)
A non-nucleoside reverse transcriptase inhibitor. Capravirine shows antiviral activity against wild-type HIV as well as HIV strains with mutations in…
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National Institutes of Health
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Related topics
Related topics
4 relations
Narrower (2)
AG-1549
S 1153
Broader (2)
Imidazoles
Sulfur Compounds
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
5α-reductase inhibitors, antiviral and anti-tumor activities of some steroidal cyanopyridinone derivatives.
A. Al-Mohizea
,
M. Al-Omar
,
M. Abdalla
,
A. Amr
International Journal of Biological…
2012
Corpus ID: 31359821
2009
2009
Novel indazole non-nucleoside reverse transcriptase inhibitors using molecular hybridization based on crystallographic overlays.
L. Jones
,
G. Allan
,
+13 authors
Chris Phillips
Journal of Medicinal Chemistry
2009
Corpus ID: 5579075
A major problem associated with non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of HIV is their lack…
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Highly Cited
2007
Highly Cited
2007
Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs).
J. Hang
,
Y. Li
,
Yanli Yang
,
N. Cammack
,
T. Mirzadegan
,
K. Klumpp
Biochemical and Biophysical Research…
2007
Corpus ID: 41948746
2006
2006
Arylthiopyrrole (AThP) Derivatives as Non‐Nucleoside HIV‐1 Reverse Transcriptase Inhibitors: Synthesis, Structure–Activity Relationships, and Docking Studies (Part 2)
A. Lavecchia
,
R. Costi
,
+6 authors
Roberto Di Santo
ChemMedChem
2006
Corpus ID: 6593927
Arylthio isopropyl pyridinylmethylpyrrolemethanols (AThPs) have been recently reported as a new class of human immunodeficiency…
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Review
2004
Review
2004
New non-nucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infections.
R. Pauwels
Current opinion in pharmacology (Print)
2004
Corpus ID: 2718998
Review
2004
Review
2004
Current status of the non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1.
J. Balzarini
Current Topics in Medicinal Chemistry
2004
Corpus ID: 42897031
Almost fifteen years ago, the first non-nucleoside reverse transcriptase (RT) inhibitor (NNRTI) lead compounds have been…
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2004
2004
Metabolism and excretion of capravirine, a new non-nucleoside reverse transcriptase inhibitor, alone and in combination with ritonavir in healthy volunteers.
Hai-zhi Bu
,
W. Pool
,
E. Wu
,
S. Raber
,
M. Amantea
,
B. Shetty
Drug Metabolism And Disposition
2004
Corpus ID: 2952085
Metabolism and disposition of capravirine, a new non-nucleoside reverse transcriptase inhibitor, were studied in healthy male…
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Review
2004
Review
2004
Non-nucleoside reverse transcriptase inhibitors (NNRTIs): past, present, and future.
E. De Clercq
Chemistry and Biodiversity
2004
Corpus ID: 44604511
Non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) have become an inherent ingredient of the drug combination schemes…
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Review
2001
Review
2001
New developments in anti-HIV chemotherapy
E. De Clercq
Current Medicinal Chemistry
2001
Corpus ID: 23439270
Abstract Virtually all the compounds that are currently used, or under advanced clinical trial, for the treatment of HIV…
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Highly Cited
2001
Highly Cited
2001
Antiviral drugs: current state of the art.
E. De Clercq
Journal of Clinical Virology
2001
Corpus ID: 37871480
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