capravirine

Known as: (5-(3,5-dichlorophenyl)sulfanyl-4-propan-2-yl-1-(pyridin-4-ylmethyl)imidazol-2-yl)methyl aminoformate, 1H-Imidazole-2-methanol, 5-((3,5-dichlorophenyl)thio)-4-(1-methylethyl)-1-(4-pyridinylmethyl)-, carbamate (ester), 5-((3,5-Dichlorophenyl)thio)-4-isopropyl-1-(4-pyridylmethyl)imidazole-2-methanol Carbamate (ester) 
A non-nucleoside reverse transcriptase inhibitor. Capravirine shows antiviral activity against wild-type HIV as well as HIV strains with mutations in… (More)
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (2)

AG-1549S 1153

Broader (2)

ImidazolesSulfur Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Evaluation of capravirine as a CYP3A probe substrate: in vitro and in vivo metabolism of capravirine in rats and dogs.
Metabolism of [(14)C]capravirine was studied via both in vitro and in vivo means in rats and dogs. Mass balance was achieved in… (More)
Is this relevant?
2006
2006
Identification of enzymes responsible for primary and sequential oxygenation reactions of capravirine in human liver microsomes.
Capravirine, a new non-nucleoside reverse transcriptase inhibitor, undergoes extensive oxygenation reactions, including N… (More)
  • figure 1
  • figure 2
  • table 1
Is this relevant?
2005
2005
A simple sequential incubation method for deconvoluting the complicated sequential metabolism of capravirine in humans.
Capravirine, a non-nucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus type 1, undergoes… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2005
2005
Synthesis of 2-(aminocarbonylmethylthio)-1H-imidazoles as novel Capravirine analogues.
Different analogues of Capravirine (AG-1549) or S-1153 were prepared by synthesis of 2-(5-benzyl-4-isopropyl-1-methyl-2,3-dihydro… (More)
Is this relevant?
Review
2005
Review
2005
Emerging anti-HIV drugs.
There are now exactly 20 anti-HIV drugs licenced (approved) for clinical use, and > 30 anti-HIV compounds under (pre)clinical… (More)
Is this relevant?
2004
2004
Capravirine, a nonnucleoside reverse-transcriptase inhibitor in patients infected with HIV-1: a phase 1 study.
Capravirine is a nonnucleoside reverse-transcriptase inhibitor (NNRTI) with a unique resistance profile. Although single… (More)
Is this relevant?
Review
2004
Review
2004
New non-nucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infections.
Despite the availability of 20 approved anti-retroviral drugs for the treatment of HIV infection, there is still a need for new… (More)
Is this relevant?
Review
2004
Review
2004
Current status of the non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1.
Almost fifteen years ago, the first non-nucleoside reverse transcriptase (RT) inhibitor (NNRTI) lead compounds have been… (More)
Is this relevant?
2004
2004
Metabolism and excretion of capravirine, a new non-nucleoside reverse transcriptase inhibitor, alone and in combination with ritonavir in healthy volunteers.
Metabolism and disposition of capravirine, a new non-nucleoside reverse transcriptase inhibitor, were studied in healthy male… (More)
  • figure 1
  • figure 2
  • table 1
  • table 2
  • figure 3
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Antiviral drugs: current state of the art.
The chemotherapy of virus infections has definitely come of age. There are now 15 antiviral agents that have been formally… (More)
Is this relevant?