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capravirine

Known as: (5-(3,5-dichlorophenyl)sulfanyl-4-propan-2-yl-1-(pyridin-4-ylmethyl)imidazol-2-yl)methyl aminoformate, 1H-Imidazole-2-methanol, 5-((3,5-dichlorophenyl)thio)-4-(1-methylethyl)-1-(4-pyridinylmethyl)-, carbamate (ester), 5-((3,5-Dichlorophenyl)thio)-4-isopropyl-1-(4-pyridylmethyl)imidazole-2-methanol Carbamate (ester) 
A non-nucleoside reverse transcriptase inhibitor. Capravirine shows antiviral activity against wild-type HIV as well as HIV strains with mutations in… 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (2)

AG-1549S 1153

Broader (2)

ImidazolesSulfur Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
5α-reductase inhibitors, antiviral and anti-tumor activities of some steroidal cyanopyridinone derivatives.
2006
2006
Arylthiopyrrole (AThP) Derivatives as Non‐Nucleoside HIV‐1 Reverse Transcriptase Inhibitors: Synthesis, Structure–Activity Relationships, and Docking Studies (Part 2)
Arylthio isopropyl pyridinylmethylpyrrolemethanols (AThPs) have been recently reported as a new class of human immunodeficiency… 
2006
2006
Identification of Enzymes Responsible for Primary and Sequential Oxygenation Reactions of Capravirine in Human Liver Microsomes
Capravirine, a new non-nucleoside reverse transcriptase inhibitor, undergoes extensive oxygenation reactions, including N… 
2005
2005
A SIMPLE SEQUENTIAL INCUBATION METHOD FOR DECONVOLUTING THE COMPLICATED SEQUENTIAL METABOLISM OF CAPRAVIRINE IN HUMANS
Capravirine, a non-nucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus type 1, undergoes… 
2005
2005
Synthesis of 2-(aminocarbonylmethylthio)-1H-imidazoles as novel Capravirine analogues.
Review
2004
Review
2004
New non-nucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infections.
  • R. Pauwels
  • Current opinion in pharmacology (Print)
  • 2004
  • Corpus ID: 2718998
Review
2004
Review
2004
Current status of the non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1.
Almost fifteen years ago, the first non-nucleoside reverse transcriptase (RT) inhibitor (NNRTI) lead compounds have been… 
2004
2004
Metabolism and excretion of capravirine, a new non-nucleoside reverse transcriptase inhibitor, alone and in combination with ritonavir in healthy volunteers.
Metabolism and disposition of capravirine, a new non-nucleoside reverse transcriptase inhibitor, were studied in healthy male… 
2004
2004
Capravirine, a nonnucleoside reverse-transcriptase inhibitor in patients infected with HIV-1: a phase 1 study.
Capravirine is a nonnucleoside reverse-transcriptase inhibitor (NNRTI) with a unique resistance profile. Although single… 
Review
2004
Review
2004
New antiretroviral agents for the treatment of HIV infection
Issues, such as complexity, tolerability, and drug resistance and cross-resistance, limit the effectiveness of current… 
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