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capravirine

Known as: (5-(3,5-dichlorophenyl)sulfanyl-4-propan-2-yl-1-(pyridin-4-ylmethyl)imidazol-2-yl)methyl aminoformate, 1H-Imidazole-2-methanol, 5-((3,5-dichlorophenyl)thio)-4-(1-methylethyl)-1-(4-pyridinylmethyl)-, carbamate (ester), 5-((3,5-Dichlorophenyl)thio)-4-isopropyl-1-(4-pyridylmethyl)imidazole-2-methanol Carbamate (ester) 
A non-nucleoside reverse transcriptase inhibitor. Capravirine shows antiviral activity against wild-type HIV as well as HIV strains with mutations in… 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (2)

AG-1549S 1153

Broader (2)

ImidazolesSulfur Compounds

Papers overview

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2012
2012
5α-reductase inhibitors, antiviral and anti-tumor activities of some steroidal cyanopyridinone derivatives.
Review
2012
Review
2012
The HIV-1 non-nucleoside reverse transcriptase inhibitors (part V): capravirine and its analogues.
Capravirine (S-1153, AG1549), a 1,2,4,5-tetrasubstituted imidazole derivative, was firstly reported by the Shionogi company to… 
2008
2008
Highlights of the Society for Medicines
The discovery of new therapies for the treatment of delayed gastric emptying represents an opportunity to offer improved… 
2007
2007
Evaluation of Capravirine as a CYP3A Probe Substrate: In Vitro and in Vivo Metabolism of Capravirine in Rats and Dogs
Metabolism of [14C]capravirine was studied via both in vitro and in vivo means in rats and dogs. Mass balance was achieved in… 
2007
2007
A unique example of drug metabolism: tetra- and penta-oxygenation reactions of capravirine in rats, dogs and humans.
Six tetra- and two penta-oxygenated capravirine metabolites observed in rats, dogs and humans represent the maximum numbers of… 
2005
2005
Synthesis of 2-(aminocarbonylmethylthio)-1H-imidazoles as novel Capravirine analogues.
2004
2004
Capravirine, a nonnucleoside reverse-transcriptase inhibitor in patients infected with HIV-1: a phase 1 study.
Capravirine is a nonnucleoside reverse-transcriptase inhibitor (NNRTI) with a unique resistance profile. Although single… 
Review
2004
Review
2004
New antiretroviral agents for the treatment of HIV infection
Issues, such as complexity, tolerability, and drug resistance and cross-resistance, limit the effectiveness of current… 
2003
2003
Capravirine: Anti-HIV agent prop inn reverse transcriptase inhibitor
Introduction of highly active antiretroviral therapy (HAART) including reverse transcriptase (RT) inhibitors has been effective… 
2003
2003
Traitement d'une infection par le vih par administration combinee de tipranavir et de capravirine
L'invention concerne une methode de traitement amelioree d'une infection par le VIH, consistant a administrer a un humain… 
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