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capravirine

Known as: (5-(3,5-dichlorophenyl)sulfanyl-4-propan-2-yl-1-(pyridin-4-ylmethyl)imidazol-2-yl)methyl aminoformate, 1H-Imidazole-2-methanol, 5-((3,5-dichlorophenyl)thio)-4-(1-methylethyl)-1-(4-pyridinylmethyl)-, carbamate (ester), 5-((3,5-Dichlorophenyl)thio)-4-isopropyl-1-(4-pyridylmethyl)imidazole-2-methanol Carbamate (ester) 
A non-nucleoside reverse transcriptase inhibitor. Capravirine shows antiviral activity against wild-type HIV as well as HIV strains with mutations in… Expand
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (2)

AG-1549S 1153

Broader (2)

ImidazolesSulfur Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
In vitro selection of mutations in human immunodeficiency virus type 1 reverse transcriptase that confer resistance to capravirine, a novel nonnucleoside reverse transcriptase inhibitor.
Capravirine (CPV; formerly AG1549 and S-1153) is a novel, nonnucleoside reverse transcriptase inhibitor (NNRTI) of human… Expand
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2005
2005
Synthesis of 2-(aminocarbonylmethylthio)-1H-imidazoles as novel Capravirine analogues.
Different analogues of Capravirine (AG-1549) or S-1153 were prepared by synthesis of 2-(5-benzyl-4-isopropyl-1-methyl-2,3-dihydro… Expand
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2005
2005
A SIMPLE SEQUENTIAL INCUBATION METHOD FOR DECONVOLUTING THE COMPLICATED SEQUENTIAL METABOLISM OF CAPRAVIRINE IN HUMANS
Capravirine, a non-nucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus type 1, undergoes… Expand
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Review
2004
Review
2004
Current status of the non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1.
  • J. Balzarini
  • Current topics in medicinal chemistry
  • 2004
    • Corpus ID: 42897031
Almost fifteen years ago, the first non-nucleoside reverse transcriptase (RT) inhibitor (NNRTI) lead compounds have been… Expand
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2004
2004
Metabolism and excretion of capravirine, a new non-nucleoside reverse transcriptase inhibitor, alone and in combination with ritonavir in healthy volunteers.
Metabolism and disposition of capravirine, a new non-nucleoside reverse transcriptase inhibitor, were studied in healthy male… Expand
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Review
2004
Review
2004
New non-nucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infections.
  • R. Pauwels
  • Current opinion in pharmacology
  • 2004
    • Corpus ID: 2718998
Despite the availability of 20 approved anti-retroviral drugs for the treatment of HIV infection, there is still a need for new… Expand
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Review
2004
Review
2004
Non-nucleoside reverse transcriptase inhibitors (NNRTIs): past, present, and future.
Non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) have become an inherent ingredient of the drug combination schemes… Expand
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2004
2004
Capravirine, a nonnucleoside reverse-transcriptase inhibitor in patients infected with HIV-1: a phase 1 study.
Capravirine is a nonnucleoside reverse-transcriptase inhibitor (NNRTI) with a unique resistance profile. Although single… Expand
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Review
2001
Review
2001
New developments in anti-HIV chemotherapy
  • E. De Clercq
  • Current medicinal chemistry
  • 2001
    • Corpus ID: 23439270
Virtually all the compounds that are currently used, or under advanced clinical trial, for the treatment of HIV infections… Expand
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Highly Cited
2001
Highly Cited
2001
Antiviral drugs: current state of the art.
  • E. De Clercq
  • Journal of clinical virology : the official…
  • 2001
    • Corpus ID: 37871480
The chemotherapy of virus infections has definitely come of age. There are now 15 antiviral agents that have been formally… Expand
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