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National survey of extended-interval aminoglycoside dosing.
A random sample survey of 500 acute care hospitals in the United States was conducted to evaluate the adoption of extended-interval aminoglycoside dosing (EIAD). The survey revealed that EIAD hasExpand
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Outpatient parenteral antimicrobial-drug therapy.
Over the past 20 years, outpatient parenteral therapy with antimicrobial drugs has proved effective, safe, and cost effective for patients with a wide range of infectious diseases.1–4 Teams to manageExpand
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A Phase 2, Randomized, Dose-Response Trial of Taprenepag Isopropyl (PF-04217329) Versus Latanoprost 0.005% in Open-Angle Glaucoma and Ocular Hypertension
Purpose: To evaluate the safety of escalating doses of taprenepag isopropyl (PF-04217329), a selective EP2 receptor agonist administered as a topical ophthalmic solution, versus its vehicle (StageExpand
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Ritonavir 100 mg Does Not Cause QTc Prolongation in Healthy Subjects: A Possible Role as CYP3A Inhibitor in Thorough QTc Studies
To assess the QTc prolongation by ritonavir (RTV) 100 mg and explore its potential use as CYP3A inhibitor in thorough QTc (TQT) studies. Randomized, crossover study of single‐dose RTV 100 mg,Expand
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Metabolism and excretion of capravirine, a new non-nucleoside reverse transcriptase inhibitor, alone and in combination with ritonavir in healthy volunteers.
Metabolism and disposition of capravirine, a new non-nucleoside reverse transcriptase inhibitor, were studied in healthy male volunteers who were randomly divided into two groups (A and B) with fiveExpand
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Latanoprost systemic exposure in pediatric and adult patients with glaucoma: a phase 1, open-label study.
OBJECTIVE To evaluate short-term safety and steady-state systemic pharmacokinetics (PK) of latanoprost acid in pediatric subjects with glaucoma or ocular hypertension who received the adultExpand
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A Model‐Based Meta‐Analysis of the Effect of Latanoprost Chronotherapy on the Circadian Intraocular Pressure of Patients With Glaucoma or Ocular Hypertension
Several reports have demonstrated that the efficacy of latanoprost is influenced by the time of dosing. This model‐based meta‐analysis validates previous findings that evening dosing is superior toExpand
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Pharmacodynamics of Glycopeptides in the Mouse Peritonitis Model of Streptococcus pneumoniae orStaphylococcus aureus Infection
ABSTRACT The emergence of resistance to various antibiotics in pneumococci leaves the glycopeptides as the only antibiotics against which pneumococci have no resistance mechanism. This situation hasExpand
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The effects of cyclosporine on the pharmacokinetics of doxorubicin in patients with small cell lung cancer
Background. The authors compared the pharmacokinetics of doxorubicin when administered with and without concomitant high dose cyclosporine for multidrug resistant (MDR) tumor modulation in small cellExpand
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