• Publications
  • Influence
Genome sequence of Halobacterium species NRC-1.
TLDR
Analysis of the genome sequence shows the presence of pathways for uptake and utilization of amino acids, active sodium-proton antiporter and potassium uptake systems, sophisticated photosensory and signal transduction pathways, and DNA replication, transcription, and translation systems resembling more complex eukaryotic organisms.
SPECTRAL AND PHOTOCHEMICAL PROPERTIES OF CURCUMIN
TLDR
Findings indicate that the spectral and photochemical properties of curcumin are strongly influenced by solvent and in biological systems, singlet oxygen, superoxide and products of photodegradation may all participate inCurcumin phototoxicity depending on the environment of the dye.
Safety, Pharmacokinetics, and Biological Pharmacodynamics of the Immunocytokine EMD 273066 (huKS-IL2): Results of a Phase I Trial in Patients with Prostate Cancer
TLDR
The data demonstrate that the novel immunocytokine EMD 273066 is well tolerated at doses above a level of observed systemic biologic activity in patients with androgen-independent prostate cancer.
Comparison of killing of gram-negative and gram-positive bacteria by pure singlet oxygen
TLDR
The outer membrane-lipopolysaccharide portion of the gram-negative cell wall initially protects the bacteria from extracellular singlet oxygen, although it may also serve as a source for secondary reaction products which accentuate the rates of cell killing.
Photokilling of bacteria by the natural dye curcumin
TLDR
Curcumin binding to cells was not required for photokilling; the reactive intermediate therefore must be relatively long-lived, and the mechanism(s) of curcumin phototoxicity may involve hydrogen peroxide production.
Readily available fluorescein isothiocyanate-conjugated antibodies can be easily converted into targeted phototoxic agents for antibacterial, antiviral, and anticancer therapy.
TLDR
Results demonstrate that iodination did not destroy the specificity or activity of the antibody, and provides a simple way to rapidly prepare a large number of targeted phototoxic agents that can be used for the selective destruction with light of nearly any type of tissue or organism.
PURE SINGLET OXYGEN CYTOTOXICITY FOR BACTERIA
TLDR
Physical separation of the photosensitizer and the bacteria eliminates the possibility of direct interaction between bacteria and photoexcited sensitizers that could lead to Type I (non‐singlet oxygen) photooxidation processes, which was used to examine the bacterial cytotoxicity of singlet oxygen.
Potentiation of Azole Antifungals by 2-Adamantanamine
TLDR
AC17, a close structural analog to the antiviral amantadine, did not affect the viability of C. albicans but caused the normally fungistatic azoles to become fungicidal, and is a promising lead in the search for more effective antifungal therapeutics.
SOME PREVALENT BIOMOLECULES AS DEFENSES AGAINST SINGLET OXYGEN DAMAGE
TLDR
It is concluded that some prevalent biomolecules may afford protection either by preventing singlet oxygen production (urate, L‐ergothioneine) or by intercepting singinglet oxygen once formed (L‐carnosine).
...
1
2
3
4
5
...