canakinumab

Known as: immunoglobulin G1, anti-(human interleukin 1beta) (human clone ACZ885 heavy chain V region) 
A recombinant monoclonal antibody targeting human interleukin-1 beta (IL-1b), with anti-inflammatory and immunomodulating activities. Canakinumab… (More)
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
BACKGROUND Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk… (More)
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Review
2017
Review
2017
The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary mechanism of action is the… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Interleukin-1 is pivotal in the pathogenesis of systemic juvenile idiopathic arthritis (JIA). We assessed the efficacy… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND To test formally the inflammatory hypothesis of atherothrombosis, an agent is needed that reduces inflammatory… (More)
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Highly Cited
2012
Highly Cited
2012
OBJECTIVES Gouty arthritis patients for whom non-steroidal anti-inflammatory drugs and colchicine are inappropriate have limited… (More)
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Review
2012
Review
2012
Interleukin-1 (IL-1) is a highly active pro-inflammatory cytokine that lowers pain thresholds and damages tissues. Monotherapy… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Inflammation contributes to all phases of the atherothrombotic process, and patients with elevated inflammatory… (More)
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Highly Cited
2011
Highly Cited
2011
OBJECTIVE Longer-term effects of prolonged selective interleukin-1β blockade with canakinumab were evaluated in the largest… (More)
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Highly Cited
2010
Highly Cited
2010
OBJECTIVE To assess the efficacy and tolerability of canakinumab, a fully human anti-interleukin-1β monoclonal antibody, for the… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND The cryopyrin-associated periodic syndrome (CAPS) is a rare inherited inflammatory disease associated with… (More)
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