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Inflammation in atherosclerosis
The new appreciation of the role of inflammation in atherosclerosis provides a mechanistic framework for understanding the clinical benefits of lipid-lowering therapies and unravelling the details of inflammatory pathways may eventually furnish new therapeutic targets.
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Antiinflammatory therapy targeting the interleukin‐1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid‐level lowering.
Inflammation and Atherosclerosis
New insights into inflammation in atherosclerosis not only increase the understanding of this disease, but also have practical clinical applications in risk stratification and targeting of therapy for this scourge of growing worldwide importance.
Inflammation in Atherosclerosis
  • P. Libby
  • Biology, Medicine
    Arteriosclerosis, thrombosis, and vascular…
  • 1 September 2012
The discovery of the immune basis of allograft arteriosclerosis demonstrated that inflammation per se can drive arterial hyperplasia, even in the absence of traditional risk factors.
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.
Progress and challenges in translating the biology of atherosclerosis
Understanding how to combine experimental and clinical science will provide further insight into atherosclerosis and could lead to new clinical applications.
Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 2-Volume Set, 9th Edition Expert Consult Premium Edition €“ Enhanced Online Features
Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 2-Volume Set, 9th Edition Expert Consult Premium Edition €“ Enhanced Online Features - Libros de Medicina - Sistema Cardiovascular -
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
This work identifies two distinct phases of monocyte participation after MI and proposes a model that reconciles the divergent properties of these cells in healing and identifies new therapeutic targets that can influence healing and ventricular remodeling after MI.
The immune response in atherosclerosis: a double-edged sword
This Review focuses on the role of immune mechanisms in the formation and activation of atherosclerotic plaques, and also includes a discussion of the use of inflammatory markers for predicting cardiovascular events.
Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites
It is shown that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation and identifies splenic monocytes as a resource that the body exploits to regulate inflammation.