bromopyruvate

Known as: 3-bromopyruvate 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1967-2017
0102019672017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Tumor progression is driven by genetic mutations, but little is known about the environmental conditions that select for these… (More)
Is this relevant?
Highly Cited
2009
Highly Cited
2009
3-BrPA (3-bromopyruvate) is an alkylating agent with anti-tumoral activity on hepatocellular carcinoma. This compound inhibits… (More)
  • figure 1
  • figure 3
  • figure 2
  • figure 4
  • figure 5
Is this relevant?
2009
2009
BACKGROUND The pyruvic acid analog 3-bromopyruvate (3BrPA) is an alkylating agent known to induce cancer cell death by blocking… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
2009
Highly Cited
2009
It has long been observed that cancer cells rely more on glycolysis to generate ATP and actively use certain glycolytic metabolic… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2009
2009
3-bromopyruvate (3-BrPA), a pyruvate analog recently proposed as a possible anticancer drug, was investigated in relation to its… (More)
Is this relevant?
2008
2008
Hexokinase type II (HK II) is the key enzyme for maintaining increased glycolysis in cancer cells where it is overexpressed. 3… (More)
  • figure 1
  • figure 3
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
2004
Highly Cited
2004
A common feature of many advanced cancers is their enhanced capacity to metabolize glucose to lactic acid. In a challenging study… (More)
  • figure 1
  • table 1
  • figure 2
  • table 2
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Most types of cancer are difficult to eradicate and some, like liver carcinomas, are almost always fatal. Significantly, we… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
The rabbit VX2 tumor when implanted in the liver has proven convenient as a model for studying hepatocellular carcinomas. However… (More)
Is this relevant?
1990
1990
The inactivation of tetrameric isocitrate lyase from Escherichia coli by 3-bromopyruvate, exhibiting saturation kinetics, is… (More)
Is this relevant?