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Principles for the post-GWAS functional characterization of cancer risk loci
Genome wide association studies (GWAS) have identified more than 200 mostly new common low-penetrance susceptibility loci for cancers. The predicted risk associated with each locus is generally… Expand
A high performance test of differential gene expression for oligonucleotide arrays
Logit-t employs a logit-transformation for normalization followed by statistical testing at the probe-level. Using four publicly-available datasets, together providing 2,710 known positive incidences… Expand
Wildtype Kras2 can inhibit lung carcinogenesis in mice
Although the ras genes have long been established as proto-oncogenes, the dominant role of activated ras in cell transformation has been questioned. Previous studies have shown frequent loss of the… Expand
A Gene Expression Signature Predicts Survival of Patients with Stage I Non-Small Cell Lung Cancer
Background Lung cancer is the leading cause of cancer-related death in the United States. Nearly 50% of patients with stages I and II non-small cell lung cancer (NSCLC) will die from recurrent… Expand
Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing.
Lung cancer is the leading cause of cancer-related death, with non-small cell lung cancer (NSCLC) being the predominant form of the disease. Most lung cancer is caused by the accumulation of genomic… Expand
MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer.
About 30% stage I non-small cell lung cancer (NSCLC) patients undergoing resection will recur. Robust prognostic markers are required to better manage therapy options. MicroRNAs (miRNAs) are a class… Expand
Conserved recurrent gene mutations correlate with pathway deregulation and clinical outcomes of lung adenocarcinoma in never-smokers
BackgroundNovel and targetable mutations are needed for improved understanding and treatment of lung cancer in never-smokers.MethodsTwenty-seven lung adenocarcinomas from never-smokers were sequenced… Expand
At least four loci and gender are associated with susceptibility to the chemical induction of lung adenomas in A/J x BALB/c mice.
Four putative quantitative trait loci (QTLs) that influence susceptibility to the induction of lung adenomas by urethane in an F2 cross between A/J and BALB/cOlaHsd have been mapped. Following… Expand
Chemoprevention of lung cancer by tea.
Tea is the second only to water as the most consumed beverage in the world. Both green and black teas have been studied for their health benefits for a variety of diseases, particularly cancer. Lung… Expand
Patterns and functional implications of rare germline variants across 12 cancer types
Large-scale cancer sequencing data enable discovery of rare germline cancer susceptibility variants. Here we systematically analyse 4,034 cases from The Cancer Genome Atlas cancer cases representing… Expand