bosutinib

Known as: 4-Anilino-3-quinolinecarbonitrile, 4-Anilinobenzo(g)quinoline-3-carbonitrile, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile 
A synthetic quinolone derivative and dual kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity. Unlike… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Bosutinib is an oral, dual SRC/ABL tyrosine kinase inhibitor (TKI) with clinical activity in Philadelphia chromosome-positive (Ph… (More)
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2014
2014
Kinase inhibitors are important cancer drugs, but they tend to display limited target specificity, and their target profiles are… (More)
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Highly Cited
2014
Highly Cited
2014
Ponatinib is the only currently approved tyrosine kinase inhibitor (TKI) that suppresses all BCR-ABL1 single mutants in… (More)
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Highly Cited
2012
Highly Cited
2012
PURPOSE Bosutinib is an oral Src/Abl tyrosine kinase inhibitor. The phase III Bosutinib Efficacy and Safety in Newly Diagnosed… (More)
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Highly Cited
2012
Highly Cited
2012
Bosutinib, a dual Src/Abl tyrosine kinase inhibitor (TKI), has shown potent activity against chronic myeloid leukemia (CML). This… (More)
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2012
2012
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein. The Abl inhibitors imatinib… (More)
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Highly Cited
2011
Highly Cited
2011
Bosutinib, a dual Src/Abl kinase inhibitor, has shown potent activity against chronic myeloid leukemia (CML). In this phase 1/2… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND AND PURPOSE ABC multidrug transporters (MDR-ABC proteins) cause multiple drug resistance in cancer and may be involved… (More)
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Highly Cited
2008
Highly Cited
2008
Src family kinase activity is elevated in many human tumors, including breast cancer, and is often associated with aggressive… (More)
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Highly Cited
2007
Highly Cited
2007
We describe a chemical proteomics approach to profile the interaction of small molecules with hundreds of endogenously expressed… (More)
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