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beta-Lactamase

Known as: Beta lactamase, beta-Lactamases [Chemical/Ingredient], Beta lactamases 
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
OBJECTIVES To develop a rapid and reliable tool to detect by multiplex PCR assays the most frequently widespread beta-lactamase… Expand
Review
2005
Review
2005
The β-lactamases are the major bacterial defense of gram-negative bacteria against β-lactam antibiotics. This review details the… Expand
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Review
1995
Review
1995
  • D. Livermore
  • Clinical microbiology reviews
  • 1995
  • Corpus ID: 5002087
beta-Lactamases are the commonest single cause of bacterial resistance to beta-lactam antibiotics. Numerous chromosomal and… Expand
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Review
1995
Review
1995
A classification scheme for b-lactamases based on functional characteristics is presented. Three major groups of enzymes are… Expand
Review
1991
Review
1991
as cefotaxime, ceftazidime, and aztreonam, antibiotics that were designed to be effective against strains producing known plasmid… Expand
Review
1989
Review
1989
The elaboration of r-lactamase-mediated resistance in bacteria has involved increased prevalence in certain organisms (notably… Expand
Highly Cited
1988
Highly Cited
1988
Before 1985 at the Pitié-Salpêtrière Hospital in Paris (2,400 beds), resistance to cefotaxime in clinical isolates of… Expand
Highly Cited
1982
Highly Cited
1982
We constructed a series of recombinant genomes which directed expression of the enzyme chloramphenicol acetyltransferase (CAT) in… Expand
Highly Cited
1980
Highly Cited
1980
  • R. Ambler
  • Philosophical transactions of the Royal Society…
  • 1980
  • Corpus ID: 32518904
The beta-lactamases are widely distributed in both Gram-positive and Gram-negative bacteria. They all inactivate penicillins and… Expand
Highly Cited
1977
Highly Cited
1977
A novel β-lactamase inhibitor has been isolated from Streptomyces clavuligerus ATCC 27064 and given the name clavulanic acid… Expand
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