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To develop a rapid and reliable tool to detect by multiplex PCR assays the most frequently widespread beta-lactamase… Expand The β-lactamases are the major bacterial defense of gram-negative bacteria against β-lactam antibiotics. This review details the… Expand beta-Lactamases are the commonest single cause of bacterial resistance to beta-lactam antibiotics. Numerous chromosomal and… Expand A classification scheme for b-lactamases based on functional characteristics is presented. Three major groups of enzymes are… Expand as cefotaxime, ceftazidime, and aztreonam, antibiotics that were designed to be effective against strains producing known plasmid… Expand The elaboration of r-lactamase-mediated resistance in bacteria has involved increased prevalence in certain organisms (notably… Expand Before 1985 at the Pitié-Salpêtrière Hospital in Paris (2,400 beds), resistance to cefotaxime in clinical isolates of… Expand We constructed a series of recombinant genomes which directed expression of the enzyme chloramphenicol acetyltransferase (CAT) in… Expand The beta-lactamases are widely distributed in both Gram-positive and Gram-negative bacteria. They all inactivate penicillins and… Expand A novel β-lactamase inhibitor has been isolated from Streptomyces clavuligerus ATCC 27064 and given the name clavulanic acid… Expand