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beta-Lactamase

Known as: Beta lactamase, beta-Lactamases [Chemical/Ingredient], Beta lactamases 
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these… 
National Institutes of Health

Related topics

Related topics

50 relations

Broader (1)

Amidohydrolases

Narrower (44)

AmpC beta-lactamasesCMY-10 beta-lactamaseCTX-M-27, E coliCTX-M-4 protein, Salmonella typhimurium
Beta Lactamase Screening MethodBeta lactamase.extended spectrum:Susc:Pt:Isolate:OrdQnIn BloodProcess of secretion

Papers overview

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Highly Cited
2005
Highly Cited
2005
Representation of Zn(II) complexes in polarizable molecular mechanics. Further refinements of the electrostatic and short‐range contributions. Comparisons with parallel ab initio computations
We present refinements of the SIBFA molecular mechanics procedure to represent the intermolecular interaction energies of Zn(II… 
Highly Cited
2004
Highly Cited
2004
Crystal Structures of the Apo and Penicillin-acylated Forms of the BlaR1 β-Lactam Sensor of Staphylococcus aureus*
Staphylococcus aureus is among the most prevalent and antibiotic-resistant of pathogenic bacteria. The resistance of S. aureus to… 
Highly Cited
1998
Highly Cited
1998
Antimicrobial Susceptibilities ofPorphyromonas gingivalis, Prevotella intermedia, and Prevotella nigrescens spp. Isolated in Spain
ABSTRACT The susceptibilities of 143 Porphyromonas gingivalis,Prevotella intermedia, and Prevotella nigrescens isolates to 18… 
Highly Cited
1995
Highly Cited
1995
Role of bacterial interference and beta-lactamase-producing bacteria in the failure of penicillin to eradicate group A streptococcal pharyngotonsillitis.
OBJECTIVE To determine the association among bacterial interference and beta-lactamase production and penicillin failure in… 
Review
1993
Review
1993
A comparative study of class-D beta-lactamases.
Three class-D beta-lactamases (OXA2, OXA1 and PSE2) were produced and purified to protein homogeneity. 6 beta-Iodopenicillanate… 
Highly Cited
1985
Highly Cited
1985
Role of beta-lactamases and outer membrane proteins in multiple beta-lactam resistance of Enterobacter cloacae
The chromosomal beta-lactamase and outer membrane proteins of Enterobacter cloacae were examined to determine their relative… 
Highly Cited
1981
Highly Cited
1981
Inactivation of the RTEM beta-lactamase from Escherichia coli. Interaction of penam sulfones with enzyme.
The characteristics of the reaction of a number of mechanism-based inactivators of the RTEM beta-lactamase have suggested that a… 
Highly Cited
1981
Highly Cited
1981
Bacillus licheniformis penicillinase synthesized in Escherichia coli contains covalently linked fatty acid and glyceride.
DNA sequence analysis of the structural gene for Bacillus licheniformis penicillinase has revealed a tetrapeptide sequence of Leu… 
Highly Cited
1981
Highly Cited
1981
Inhibition of the RTEM beta-lactamase from Escherichia coli. Interaction of enzyme with derivatives of olivanic acid.
The interaction of the RTEM beta-lactamase with two derivatives of olivanic acid has been studied. The compound MM22382 (1… 
Highly Cited
1981
Highly Cited
1981
Expression and processing of bacterial beta-lactamase in the yeast Saccharomyces cerevisiae.
The mode of expression in Saccharomyces cerevisiae of the bacterial antibiotic resistance gene coding for beta-lactamase (EC 3.5… 
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