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beta-Lactamase

Known as: Beta lactamase, beta-Lactamases [Chemical/Ingredient], Beta lactamases 
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these… 
National Institutes of Health

Related topics

Related topics

50 relations

Broader (1)

Amidohydrolases

Narrower (44)

AmpC beta-lactamasesCMY-10 beta-lactamaseCTX-M-27, E coliCTX-M-4 protein, Salmonella typhimurium
Beta Lactamase Screening MethodBeta lactamase.extended spectrum:Susc:Pt:Isolate:OrdQnIn BloodProcess of secretion

Papers overview

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1985
1985
Formadicins, new monocyclic beta-lactam antibiotics of bacterial origin. I. Taxonomy, fermentation and biological activities.
A Gram-negative bacterium produces new monocyclic beta-lactam antibiotics with a formylamino substituent, named formadicins A, B… 
1984
1984
Penicillanic acid sulfone: nature of irreversible inactivation of RTEM beta-lactamase from Escherichia coli.
When penicillanic acid sulfone in large molar excess is incubated with the RTEM beta-lactamase, the enzyme becomes inactivated… 
1984
1984
6-(Methoxymethylene)penicillanic acid: inactivator of RTEM beta-lactamase from Escherichia coli.
The Z and E isomers of 6-(methoxymethylene)-penicillanic acid have been synthesized, and their interaction with the RTEM beta… 
Highly Cited
1981
Highly Cited
1981
Inactivation of the RTEM beta-lactamase from Escherichia coli. Interaction of penam sulfones with enzyme.
The characteristics of the reaction of a number of mechanism-based inactivators of the RTEM beta-lactamase have suggested that a… 
1981
1981
A set of bacterial strains for evaluation of beta-lactamase-stability of beta-lactam antibiotics.
A set of bacterial strains composed of nine bacterial groups, with each made up of three or four strains, was used to estimate… 
1979
1979
The comparative beta-lactamase resistance and inhibitory activity of 1-oxa cephalosporin, cefoxitin and cefotaxime.
The beta-lactamase stability and inhibitory activity of 1-oxa cephalosporin, (6R,7R)-7-[[carboxy(4-hydroxyphenyl)acetyl]amino]-7… 
1979
1979
Penetration through the gram-negative cell wall: a co-determinant of the efficacy of beta-lactam antibiotics.
Resistance of gram-negative bacteria to beta-lactam antibiotics is based mainly on two mechanisms: hydrolysis by beta-lactamases… 
Highly Cited
1978
Highly Cited
1978
A sulfone beta-lactam compound which acts as a beta-lactamase inhibitor.
CP-45,899 [3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3,2,0)heptane-2-carboxylic acid, 4,4-dioxide [2S-(2alpha,5alpha)]] has low… 
1978
1978
Histidine residues of zinc ligands in beta-lactamase II.
1. The Zn(II)-requiring beta-lactamase from Bacillus cereus 569/H/9, which has two zinc-binding sites, was examined by 270 MHz 1H… 
1976
1976
Membrane penicillinase of Bacillus licheniformis 749/C:sequence and possible repeated tetrapeptide structure of the phospholipopeptide region.
The membrane penicillinase (EC 3.5.2.6; penicillin amido-beta-lactamhydrolase) of Bacillus licheniforis 749/C, which appears to…