beta-Lactamase

Known as: Beta lactamase, beta-Lactamases [Chemical/Ingredient], Beta lactamases 
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these… (More)
National Institutes of Health

Papers overview

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Review
2009
Review
2009
SUMMARY AmpC beta-lactamases are clinically important cephalosporinases encoded on the chromosomes of many of the… (More)
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Review
2006
Review
2006
In the past decade CTX-M enzymes have become the most prevalent extended-spectrum beta-lactamases, both in nosocomial and in… (More)
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Review
2005
Review
2005
Extended-spectrum beta-lactamases (ESBLs) are a rapidly evolving group of beta-lactamases which share the ability to hydrolyze… (More)
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Review
2005
Review
2005
The ascendancy of metallo-beta-lactamases within the clinical sector, while not ubiquitous, has nonetheless been dramatic; some… (More)
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Highly Cited
2002
Highly Cited
2002
Therapeutic options for infections caused by gram-negative organisms expressing plasmid-mediated AmpC beta-lactamases are limited… (More)
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Review
2001
Review
2001
Beta-lactamases continue to be the leading cause of resistance to beta-lactam antibiotics among gram-negative bacteria. In recent… (More)
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Review
1995
Review
1995
A classification scheme for b-lactamases based on functional characteristics is presented. Three major groups of enzymes are… (More)
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Highly Cited
1988
Highly Cited
1988
Before 1985 at the Pitié-Salpêtrière Hospital in Paris (2,400 beds), resistance to cefotaxime in clinical isolates of… (More)
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Highly Cited
1980
Highly Cited
1980
The beta-lactamases are widely distributed in both Gram-positive and Gram-negative bacteria. They all inactivate penicillins and… (More)
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Highly Cited
1972
Highly Cited
1972
A new cephalosporin with a highly reactive beta-lactam ring was found to give an immediate color change in the presence of beta… (More)
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