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beta-Adrenergic Receptor Kinases

Known as: Receptor Kinases, beta-Adrenergic, beta-Adrenergic Receptor Kinases [Chemical/Ingredient], beta adrenergic receptor kinase 
G-protein-coupled receptor kinases that mediate agonist-dependent PHOSPHORYLATION and desensitization of BETA-ADRENERGIC RECEPTORS.
National Institutes of Health

Papers overview

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Highly Cited
1998
Highly Cited
1998
Heart failure is accompanied by severely impaired beta-adrenergic receptor (betaAR) function, which includes loss of betaAR… 
Highly Cited
1996
Highly Cited
1996
β-Arrestins are proteins that bind phosphorylated heterotrimeric GTP-binding protein (G protein)-coupled receptors (GPCRs) and… 
Highly Cited
1995
Highly Cited
1995
Transgenic mice were created with cardiac-specific overexpression of the beta-adrenergic receptor kinase-1 (beta ARK1) or a beta… 
Highly Cited
1994
Highly Cited
1994
The beta-adrenergic receptor system of the failing human heart is markedly desensitized. We have recently postulated that this… 
Highly Cited
1993
Highly Cited
1993
BACKGROUND In chronic heart failure, the positive inotropic effects of beta-adrenergic receptor agonists are greatly reduced, in… 
Highly Cited
1992
Highly Cited
1992
The rate and extent of the agonist-dependent phosphorylation of beta 2-adrenergic receptors and rhodopsin by beta-adrenergic… 
Highly Cited
1990
Highly Cited
1990
Homologous or agonist-specific desensitization of beta-adrenergic receptors is thought to be mediated by a specific kinase, the… 
Review
1990
Review
1990
Cellular responses to many hormones and neurotransmitters wane rapidly despite continuous exposure of cells to these stimuli… 
Highly Cited
1989
Highly Cited
1989
The beta-adrenergic receptor kinase (beta-ARK), which specifically phosphorylates only the agonist-occupied form of the beta… 
Highly Cited
1987
Highly Cited
1987
The beta-adrenergic receptor kinase is an enzyme, possibly analogous to rhodopsin kinase, that multiply phosphorylates the beta…