beta-Adrenergic Receptor Kinases
Semantic Scholar uses AI to extract papers important to this topic.
Heart failure is accompanied by severely impaired beta-adrenergic receptor (betaAR) function, which includes loss of betaAR… Expand Transgenic mice were created with cardiac-specific overexpression of the beta-adrenergic receptor kinase-1 (beta ARK1) or a beta… Expand The beta gamma subunits (G beta gamma) of heterotrimeric G proteins modulate the activity of several signal-transducing effector… Expand The beta-adrenergic receptor system of the failing human heart is markedly desensitized. We have recently postulated that this… Expand BACKGROUND
In chronic heart failure, the positive inotropic effects of beta-adrenergic receptor agonists are greatly reduced, in… Expand The rate and extent of the agonist-dependent phosphorylation of beta 2-adrenergic receptors and rhodopsin by beta-adrenergic… Expand Homologous or agonist-specific desensitization of beta-adrenergic receptors is thought to be mediated by a specific kinase, the… Expand Cellular responses to many hormones and neurotransmitters wane rapidly despite continuous exposure of cells to these stimuli… Expand The beta-adrenergic receptor kinase (beta-ARK), which specifically phosphorylates only the agonist-occupied form of the beta… Expand The beta-adrenergic receptor kinase is an enzyme, possibly analogous to rhodopsin kinase, that multiply phosphorylates the beta… Expand