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beta-Adrenergic Receptor Kinases

Known as: Receptor Kinases, beta-Adrenergic, beta-Adrenergic Receptor Kinases [Chemical/Ingredient], beta adrenergic receptor kinase 
G-protein-coupled receptor kinases that mediate agonist-dependent PHOSPHORYLATION and desensitization of BETA-ADRENERGIC RECEPTORS.
National Institutes of Health

Papers overview

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Highly Cited
1998
Highly Cited
1998
Heart failure is accompanied by severely impaired beta-adrenergic receptor (betaAR) function, which includes loss of betaAR… Expand
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Highly Cited
1996
Highly Cited
1996
The beta-adrenergic receptor kinase 1 (beta ARK1) is a member of the G protein-coupled receptor kinase (GRK) family that mediates… Expand
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Highly Cited
1996
Highly Cited
1996
β-Arrestins are proteins that bind phosphorylated heterotrimeric GTP-binding protein (G protein)-coupled receptors (GPCRs) and… Expand
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Highly Cited
1995
Highly Cited
1995
Transgenic mice were created with cardiac-specific overexpression of the beta-adrenergic receptor kinase-1 (beta ARK1) or a beta… Expand
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Highly Cited
1994
Highly Cited
1994
The beta-adrenergic receptor system of the failing human heart is markedly desensitized. We have recently postulated that this… Expand
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Highly Cited
1993
Highly Cited
1993
BACKGROUND In chronic heart failure, the positive inotropic effects of beta-adrenergic receptor agonists are greatly reduced, in… Expand
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Highly Cited
1992
Highly Cited
1992
The rate and extent of the agonist-dependent phosphorylation of beta 2-adrenergic receptors and rhodopsin by beta-adrenergic… Expand
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Highly Cited
1990
Highly Cited
1990
Homologous or agonist-specific desensitization of beta-adrenergic receptors is thought to be mediated by a specific kinase, the… Expand
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Review
1990
Review
1990
Cellular responses to many hormones and neurotransmitters wane rapidly despite continuous exposure of cells to these stimuli… Expand
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Highly Cited
1989
Highly Cited
1989
The beta-adrenergic receptor kinase (beta-ARK), which specifically phosphorylates only the agonist-occupied form of the beta… Expand
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