ardeemin
National Institutes of Health
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In nature, cyclic dipeptide prenyltransferases catalyze regioselective Friedel-Crafts alkylations of tryptophan-containing cyclic…
Four ardeemin derivatives, 5‐N‐acetylardeemin (1), 5‐N‐acetyl‐15bβ‐hydroxyardeemin (2), 5‐N‐acetyl‐15b‐didehydroardeemin (3), and…
Because multidrug resistance (MDR) is a serious impediment to the use of chemotherapy in treating cancer patients, great efforts…
Ardeemins are hexacyclic peptidyl alkaloids isolated from Aspergillus fischeri as agents that block efflux of anticancer drugs by…
This chapter describes the drug development process and models in the historical and future perspectives. The features of…