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Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (annual wormwood).
TLDR
Artemisia annua L. (annual wormwood) contains the antimalarial artemisinin, and plasma concentrations after intake of this herbal tea are sufficient for clinical effects, but insufficient to recommend such preparations as equivalent substitutes for modern art Artemisinin drugs in malaria therapy.
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The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria
TLDR
The x-ray structure of DMATS is determined, which shows strict regiospecificity for position 4 of the indole nucleus of tryptophan as well as unusual independence of the presence of Mg2+ ions.
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Identification of a Hybrid PKS/NRPS Required for Pseurotin A Biosynthesis in the Human Pathogen Aspergillus fumigatus
TLDR
Evidence is presented that the PKS/NRPS gene psoA is required for the biosynthesis of pseurotin A, a compound with an unusual heterospirocyclic γ‐lactam structure that is reported to be a competitive inhibitor of chitin synthase and an inducer of nerve‐cell proliferation.
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Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis.
Prenylated indole alkaloids are hybrid natural products derived from prenyl diphosphates and tryptophan or its precursors and widely distributed in filamentous fungi, especially in the genera…
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Identification of the Novobiocin Biosynthetic Gene Cluster of Streptomyces spheroides NCIB 11891
TLDR
Heterologous expression of a key enzyme of novobiocin biosynthesis, i.e., novobocic acid synthetase, in Streptomyces lividans TK24 further confirmed the involvement of the analyzed genes in the biosynthesis of the antibiotic.
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Identification of the Coumermycin A1Biosynthetic Gene Cluster of Streptomyces rishiriensisDSM 40489
TLDR
The cloned gene cluster was cloned by screening of a cosmid library of Streptomyces rishiriensis DSM 40489 with heterologous probes from a dTDP-glucose 4,6-dehydratase gene, involved in deoxysugar biosynthesis, and from the aminocoumarin resistance gyrase gene gyrBr, revealing the presence of 28 complete open reading frames (ORFs).
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NovG, a DNA-binding protein acting as a positive regulator of novobiocin biosynthesis.
TLDR
Functional proof is provided, by genetic and biochemical approaches, for the role of NovG as a positive regulator of novobiocin biosynthesis and conserved inverted repeats were identified in both fragments, similar to those identified as the binding sites for StrR.
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Resistance Genes of Aminocoumarin Producers: Two Type II Topoisomerase Genes Confer Resistance against Coumermycin A1 and Clorobiocin
TLDR
Southern hybridization experiments showed that the genome of all three antibiotic producers and of Streptomyces coelicolor contained two additional genes which hybridized with either gyrBR or parYR and which may code for aminocoumarin-sensitive GyrB and ParY proteins.
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Heterologous Expression of Novobiocin and Clorobiocin Biosynthetic Gene Clusters
TLDR
Shortening of the cosmids' inserts showed which genes are essential for antibiotic production, and λ-Red-mediated homologous recombination was used for genetic modification of the gene clusters, and the attachment site and integrase of phage φC31 were employed for the integration of these clusters into the heterologous hosts.
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Ergot alkaloids: structure diversity, biosynthetic gene clusters and functional proof of biosynthetic genes.
TLDR
Properties of most structure genes have been assigned to reaction steps in the biosynthesis of ergot alkaloid biosynthesis by gene inactivation experiments or biochemical characterisation of the overproduced proteins.
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