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aptiganel

Known as: Guanidine, N-(3-ethylphenyl)-N-methyl-N'-1-naphthalenyl 
 
National Institutes of Health

Papers overview

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Review
2004
Review
2004
It has long been accepted that high concentrations of glutamate can destroy neurons, and this is the basis of the theory of… Expand
Review
2002
Review
2002
Glutamate N-methyl-D-aspartate (NMDA) receptor antagonists (competitive receptor antagonists, ion channel blockers, and glycine… Expand
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Highly Cited
2002
Highly Cited
2002
SUMMARY During cerebral ischaemia, glutamate is released in supraphysiological amounts and is toxic to brain tissue. This… Expand
2001
2001
  • 2001
  • Corpus ID: 195161647
 
1998
1998
Recent studies have demonstrated a neuroprotective effect of the noncompetitive N-methyl-D-aspartate receptor antagonist… Expand
1998
1998
Recent studies revealed a neuroprotective effect of the non-competitive NMDA receptor antagonist Aptiganel HCL (Cerestat CNS 1102… Expand
1998
1998
Background This study determined the induction profiles of immediate‐early genes in the ovine brain after cardiopulmonary bypass… Expand
Review
1997
Review
1997
  • K. Lees
  • Neurology
  • 1997
  • Corpus ID: 45771202
A wealth of experimental evidence demonstrates that cerebral ischemia cause excessive release of glutamate and that glutamate… Expand
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1997
1997
The N-methyl-D-aspartate (NMDA) receptor is a ligand-gated ion channel which is widely distributed in the central nervous system… Expand