aptiganel

Known as: Guanidine, N-(3-ethylphenyl)-N-methyl-N'-1-naphthalenyl 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2003
012319972003

Papers overview

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2002
2002
During cerebral ischaemia, glutamate is released in supraphysiological amounts and is toxic to brain tissue. This excitotoxicity… (More)
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Review
2002
Review
2002
Glutamate N-methyl-D-aspartate (NMDA) receptor antagonists (competitive receptor antagonists, ion channel blockers, and glycine… (More)
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Highly Cited
2001
Highly Cited
2001
CONTEXT Tissue plasminogen activator is the only thrombolytic agent approved in the United States for treatment of acute ischemic… (More)
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1999
1999
BACKGROUND AND PURPOSE Aptiganel (CNS 1102) is a selective, noncompetitive antagonist that acts on the ion channel associated… (More)
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1999
1999
Those of us in the stroke field have a big job ahead of us. When I started attending this meeting 20 years ago, most of the… (More)
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1998
1998
Recent studies have demonstrated a neuroprotective effect of the noncompetitive N-methyl-D-aspartate receptor antagonist… (More)
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1998
1998
Recent studies revealed a neuroprotective effect of the non-competitive NMDA receptor antagonist Aptiganel HCL (Cerestat CNS 1102… (More)
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1998
1998
BACKGROUND This study determined the induction profiles of immediate-early genes in the ovine brain after cardiopulmonary bypass… (More)
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1997
1997
BACKGROUND Altered gene expression occurs in the brain after global ischemia. We have developed a model to examine the effects of… (More)
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1997
1997
The N-methyl-D-aspartate (NMDA) receptor is a ligand-gated ion channel which is widely distributed in the central nervous system… (More)
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