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CNS 1102

Known as: CNS-1102 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

aptiganel

Papers overview

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2010
2010
Caffeinol at the Receptor Level: Anti-Ischemic Effect of N-Methyl-d-Aspartate Receptor Blockade Is Potentiated by Caffeine
Background and Purpose— Although caffeinol (a combination of a low dose of caffeine and ethanol) was shown to robustly reduce… Expand
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Highly Cited
2006
Highly Cited
2006
Synergistic interactions between commonly used food additives in a developmental neurotoxicity test.
Exposure to non-nutritional food additives during the critical development window has been implicated in the induction and… Expand
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Highly Cited
1999
Highly Cited
1999
Safety and tolerability study of aptiganel hydrochloride in patients with an acute ischemic stroke.
BACKGROUND AND PURPOSE Aptiganel (CNS 1102) is a selective, noncompetitive antagonist that acts on the ion channel associated… Expand
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Highly Cited
1996
Highly Cited
1996
An Alternative Method for the Quantitation of Neuronal Damage after Experimental Middle Cerebral Artery Occlusion in Rats: Analysis of Behavioral Deficit
We tested the hypothesis that increasing durations of focal ischemia that have been shown to result in enlargement of cortical… Expand
1995
1995
Clinical Pharmacology of CNS 1102 in Volunteers
The high affinity noncompetitive N-methyl-D-aspartate receptor antagonist CNS 1102 (aptiganel hydrochloride, Cambridge… Expand
1995
1995
Systemic and Cerebral Hemodynamic Responses to the Noncompetitive N-Methyl-D-Aspartate (NMDA) Antagonist CNS 1102
The excitatory amino acid antagonists are being developed as neuroprotective drugs aimed at limiting ischemic neuronal damage… Expand
1994
1994
Delayed Treatment with a Noncompetitive NMDA Antagonist, CNS-1102, Reduces Infarct Size in Rats
The cerebroprotective effects of noncompetitive N-methyl- D -aspartate (NMDA) antagonists are well documented in animal focal… Expand
Highly Cited
1994
Highly Cited
1994
Graded Bioassay for Demonstration of Brain Rescue From Experimental Acute Ischemia in Rats
This study explored the correlation between duration of focal ischemia and infarct volume in spontaneously hypertensive rats as a… Expand
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Highly Cited
1994
Highly Cited
1994
Temperature Dependent Change of Apparent Diffusion Coefficient of Water in Normal and Ischemic Brain of Rats
To identify the temperature dependent change of the apparent diffusion coefficient (ADC) of water in brain tissue, the ADC values… Expand
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Highly Cited
1993
Highly Cited
1993
Diffusion and Perfusion Magnetic Resonance Imaging Studies to Evaluate a Noncompetitive N‐Methyl‐D‐aspartate Antagonist and Reperfusion in Experimental Stroke in Rats
Background and Purpose Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within minutes… Expand
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