K. Lees

Publications601
h-index88
Citations39,710
Highly Influential Citations1,015
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Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke.
TLDR
As compared with placebo, intravenous alteplase administered between 3 and 4.5 hours after the onset of symptoms significantly improved clinical outcomes in patients with acute ischemic stroke; altePlase was more frequently associated with symptomatic intracranial hemorrhage.
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Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study
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Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised…
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Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials
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Thrombolysis with alteplase 3–4·5 h after acute ischaemic stroke (SITS-ISTR): an observational study
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Interatrial septal abnormalities and stroke
TLDR
PFO and ASA are significantly associated with ischemic stroke in patients younger than 55 years and in patients aged 55 years or older, three studies produced heterogeneous results for PFO.
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The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): A Phase II MRI-Based 9-Hour Window Acute Stroke Thrombolysis Trial With Intravenous Desmoteplase
TLDR
Intravenous desmoteplase administered 3 to 9 hours after acute ischemic stroke in patients selected with perfusion/diffusion mismatch is associated with a higher rate of reperfusion and better clinical outcome compared with placebo.
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NXY-059 for the treatment of acute ischemic stroke.
TLDR
NXY-059 is ineffective for the treatment of acute ischemic stroke within 6 hours after the onset of symptoms and the hypothesis that N XY-059 would reduce alteplase-related intracranial hemorrhages was tested.
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Dual Antiplatelet Therapy With Clopidogrel and Aspirin in Symptomatic Carotid Stenosis Evaluated Using Doppler Embolic Signal Detection: The Clopidogrel and Aspirin for Reduction of Emboli in…
TLDR
In patients with recently symptomatic carotid stenosis, combination therapy with clopidogrel and aspirin is more effective than aspirin alone in reducing asymptomatic embolization.
View on Wolters Kluwer
Implementation and outcome of thrombolysis with alteplase 3–4·5 h after an acute stroke: an updated analysis from SITS-ISTR
View on Elsevier
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