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Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke.
TLDR
As compared with placebo, intravenous alteplase administered between 3 and 4.5 hours after the onset of symptoms significantly improved clinical outcomes in patients with acute ischemic stroke; altePlase was more frequently associated with symptomatic intracranial hemorrhage.
Interatrial septal abnormalities and stroke
TLDR
PFO and ASA are significantly associated with ischemic stroke in patients younger than 55 years and in patients aged 55 years or older, three studies produced heterogeneous results for PFO.
The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): A Phase II MRI-Based 9-Hour Window Acute Stroke Thrombolysis Trial With Intravenous Desmoteplase
TLDR
Intravenous desmoteplase administered 3 to 9 hours after acute ischemic stroke in patients selected with perfusion/diffusion mismatch is associated with a higher rate of reperfusion and better clinical outcome compared with placebo.
NXY-059 for the treatment of acute ischemic stroke.
TLDR
NXY-059 is ineffective for the treatment of acute ischemic stroke within 6 hours after the onset of symptoms and the hypothesis that N XY-059 would reduce alteplase-related intracranial hemorrhages was tested.
Dual Antiplatelet Therapy With Clopidogrel and Aspirin in Symptomatic Carotid Stenosis Evaluated Using Doppler Embolic Signal Detection: The Clopidogrel and Aspirin for Reduction of Emboli in
TLDR
In patients with recently symptomatic carotid stenosis, combination therapy with clopidogrel and aspirin is more effective than aspirin alone in reducing asymptomatic embolization.
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