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aptiganel hydrochloride

Known as: N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine HCl 
National Institutes of Health

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aptiganel

Papers overview

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2013
2013
Aptiganel Hydrochloride in Acute Ischemic Stroke
Highly Cited
2001
Highly Cited
2001
Aptiganel hydrochloride in acute ischemic stroke: a randomized controlled trial.
CONTEXT Tissue plasminogen activator is the only thrombolytic agent approved in the United States for treatment of acute ischemic… 
2001
2001
Ensuring patient safety in clinical trials for treatment of acute stroke.
N THIS ISSUE OF THE JOURNAL, THE APTIGANEL HYDROchloride Acute Stroke Investigators 1 present the results of yet another failed… 
Highly Cited
1999
Highly Cited
1999
Safety and tolerability study of aptiganel hydrochloride in patients with an acute ischemic stroke.
BACKGROUND AND PURPOSE Aptiganel (CNS 1102) is a selective, noncompetitive antagonist that acts on the ion channel associated… 
Review
1999
Review
1999
Ischaemic stroke: new frontiers.
Lot of advancement has taken place, not only in the management but also in the pathophysiology and imaging modalities in patients… 
1997
1997
Effects of prolonged infusions of the NMDA antagonist aptiganel hydrochloride (CNS 1102) in normal volunteers.
Blockade of the N-methyl D-aspartate (NMDA) receptor by the ion-channel-blocking drug aptiganel hydrochloride (CNS 1102, Cerestat… 
1997
1997
Immediate-early gene expression in ovine brain after hypothermic circulatory arrest: effects of aptiganel.
Review
1997
Review
1997
Development of the NMDA ion-channel blocker, aptiganel hydrochloride, as a neuroprotective agent for acute CNS injury.
1997
1997
Clinical Experience with the NMDA Ion Channel Blocker, Aptiganel Hydrochloride (CERESTAT®)
1995
1995
Clinical Pharmacology of CNS 1102 in Volunteers
The high affinity noncompetitive N-methyl-D-aspartate receptor antagonist CNS 1102 (aptiganel hydrochloride, Cambridge… 
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