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apoptolidin

 
National Institutes of Health

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1 relation

Broader (1)

Macrolides

Papers overview

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2011
2011
Biosynthesis of the Apoptolidins in Nocardiopsis sp. FU 40.
The apoptolidins are 20/21-membered macrolides produced by Nocardiopsis sp. FU40. Several members of this family are potent and… Expand
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2006
2006
Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues.
[structure: see text] Apoptolidin (1) exhibits potent and highly selective apoptosis inducing activity against sensitive cancer… Expand
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2003
2003
Total synthesis of apoptolidin: construction of enantiomerically pure fragments.
A general strategy for the total synthesis of the antitumor agent apoptolidin (1) is proposed, and the chemical synthesis of the… Expand
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2003
2003
Facile synthetic access to and biological evaluation of the macrocyclic core of apoptolidin.
Oxidative cleavage of the C-20/C-21 bond in apoptolidin (1) provides two fragments of similar complexity, facilitating a divide… Expand
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2002
2002
Isoapoptolidin: structure and activity of the ring-expanded isomer of apoptolidin.
[formula: see text] Apoptolidin (1) is a novel oncolytic lead that induces apoptosis in transformed cell lines with exceptional… Expand
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2001
2001
Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase.
BACKGROUND Apoptolidin is a macrolide originally identified on the basis of its ability to selectively kill E1A and E1A/E1B19K… Expand
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2001
2001
Total Synthesis of Apoptolidin: Part 1. Retrosynthetic Analysis and Construction of Building Blocks.
No less than 30 stereogenic elements, a highly unsaturated 20-membered macrocyclic system, four carbohydrate units, and unique… Expand
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2001
2001
Total Synthesis of Apoptolidin: Part 2. Coupling of Key Building Blocks and Completion of the Synthesis.
No less than 30 stereogenic elements, a highly unsaturated 20-membered macrocyclic system, four carbohydrate units, and unique… Expand
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2000
2000
Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase.
Recently, a family of polyketide inhibitors of F(0)F(1)-ATPase, including apoptolidin, ossamycin, and oligomycin, were shown to… Expand
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1997
1997
Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp.
Nocardiopsis sp. was found to produce a new active compound designated apoptolidin (Fig. 1). In this report, we describe the… Expand
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