apoptolidin
National Institutes of Health
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A highly convergent, enantioselective total synthesis of the potent antitumor agent apoptolidin A has been completed. The key…
A synthesis of the C(1)-C(11) fragment of apoptolidin A has been accomplished by a convergent route involving the stereoselective…
[reaction: see text] A novel approach toward the synthesis of the triene portion of the biologically active polyketide…
The total synthesis of apoptolidin (1) is reported together with the design, synthesis, and biological evaluation of a number of…
Oxidative cleavage of the C-20/C-21 bond in apoptolidin (1) provides two fragments of similar complexity, facilitating a divide…
[formula: see text] Apoptolidin (1) is a novel oncolytic lead that induces apoptosis in transformed cell lines with exceptional…
No less than 30 stereogenic elements, a highly unsaturated 20-membered macrocyclic system, four carbohydrate units, and unique…
No less than 30 stereogenic elements, a highly unsaturated 20-membered macrocyclic system, four carbohydrate units, and unique…
[reaction--see text] A stereoselective synthesis of the C(16)-C(28) fragment of the apoptosis inducing agent apoptolidin is…
Nocardiopsis sp. was found to produce a new active compound designated apoptolidin (Fig. 1). In this report, we describe the…