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7-Dehydrocholesterol metabolites produced by sterol 27-hydroxylase (CYP27A1) modulate liver X receptor activity
7-Dehydrocholesterol (7-DHC) is a common precursor of vitamin D3 and cholesterol. Although various oxysterols, oxygenated cholesterol derivatives, have been implicated in cellular signaling pathways,Expand
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High-speed recovery of antimony using chelating porous hollow-fiber membrane
A porous hollow-fiber membrane containing an iminodiethanol (IDE) group as the chelate-forming group was applied to the recovery of antimony in the permeation mode. An antimony solution was forced toExpand
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High-speed recovery of germanium in a convection-aided mode using functional porous hollow-fiber membranes.
A porous hollow-fiber membrane capable of recovery of germanium from a liquid stream was prepared by radiation-induced graft polymerization of an epoxy-group-containing vinyl monomer, glycidylExpand
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Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRalpha-selective antagonists.
Liver X receptor (LXR) alpha/beta dual agonists are candidate medicaments for the treatment of metabolic syndrome, because their biological actions include increasing cholesterol efflux mediated byExpand
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Iodine(V) reagents in organic synthesis. Part 1. Synthesis of polycyclic heterocycles via Dess-Martin periodinane-mediated cascade cyclization: generality, scope, and mechanism of the reaction.
The scope, generality, and mechanism of the Dess-Martin periodinane-mediated cyclization reaction of unsaturated anilides discovered during the total synthesis of the CP-molecules (phomoidrides A andExpand
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Anti-influenza activity of phenethylphenylphthalimide analogs derived from thalidomide.
Swine-origin influenza A virus has caused pandemics throughout the world and influenza A is regarded as a serious global health issue. Hence, novel drugs that will target these viruses are veryExpand
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Selection of a precursor monomer for the introduction of affinity ligands onto a porous membrane by radiation-induced graft polymerization
A scheme for the coupling of a ligand onto a porous membrane was selected based on criteria of permeability of liquid and adsorptivity of protein. Two precursor monomers, i.e., acrylic acid (AAc) andExpand
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Protein Adsorption and Elution Performances of Porous Hollow‐Fiber Membranes Containing Various Hydrophobic Ligands
Phenyl and butyl groups as hydrophobic ligands for protein binding were appended to the poly(glycidyl methacrylate) chain grafted onto a pore surface of a porous polyethylene hollow‐fiber membraneExpand
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Radiation-induced graft polymerization is the key to develop high-performance functional materials for protein purification
We have described a preparation scheme for immobilizing polymer chains at a uniformly high density onto a microfiltration membrane. Highly efficient protein recovery was demonstrated by the resultsExpand
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Module performance of anion-exchange porous hollow-fiber membranes for high-speed protein recovery
Abstract A laboratory-scale module was fabricated by housing eight anion-exchange porous hollow-fiber membranes with an effective length of 8 cm in parallel to each other in a cartridge. The hollowExpand
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