Studies on the synthesis of apoptolidin A. 1. Synthesis of the C(1)-C(11) fragment.


A synthesis of the C(1)-C(11) fragment of apoptolidin A has been accomplished by a convergent route involving the stereoselective glycosidation of 9 and the Suzuki cross-coupling reaction of bromodienoate 7 and the vinylborane generated via chemoselective hydroboration of diyne 6 with diisopinocampheylborane. 
DOI: 10.1021/jo702250z


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