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aplidin

National Institutes of Health

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aplidine

Papers overview

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Review
2013
Review
2013
Plitidepsin: an orphan drug
Introduction: Plitidepsin (Aplidin®) is a second-generation didemnin compound that belongs to drugs derived from natural oceanic… 
2010
2010
Aplidin as a potential adjunct to radiation therapy: In vitro studies
Purpose: Aplidin (plitidespin) is a novel cyclic depsipeptide, currently in Phase II clinical trials for solid and hematologic… 
2009
2009
Initial testing of aplidin by the pediatric pre‐clinical testing program
Aplidin was tested in vitro at concentrations ranging from from 0.1 nM to 1.0 µM and in vivo at a dose of 0.6 mg/kg administered… 
2007
2007
JNK activation as an in vivo marker of Aplidin® activity.
5580 Aplidin® (Plitidepsin) is an anti-tumoral agent from marine origin currently under Phase II clinical trials against multiple… 
2006
2006
Aplidin® combination with chemotherapeutic agents in human melanoma tumors
2134 Aplidin ® (APLD), a natural compound derived from the Mediterranean tunicate Aplidium albicans, is an antitumor agent that… 
2005
2005
Preliminary Report from an Exploratory Phase II Trial with Plitidepsin (Aplidin®) in Patients with Refractory/Relapsed Multiple Myeloma.
Introduction and objectives : Plitidepsin is a cyclic depsipeptide originally isolated from the marine tunicate, Aplidium… 
Review
2005
Review
2005
Mediterranean and Black Sea organisms and algae from mariculture as sources of antitumor drugs.
Mussels and tunicates cultivated in Mediterranean and Black Sea are the sources of antitumor drugs. Three compounds isolated from… 
Review
2004
Review
2004
Progress in the clinical development of new marine-derived anticancer compounds.
Naturally derived anticancer agents continue to be instrumental in the systemic therapeutic intervention against solid tumors and… 
2004
2004
Determination of aplidin, a marine-derived anticancer drug, in human plasma, whole blood and urine by liquid chromatography with electrospray ionisation tandem mass spectrometric detection.
2003
2003
Development of a liquid chromatography/tandem mass spectrometry assay for the quantification of Aplidin, a novel marine-derived antineoplastic agent, in human plasma.
A rapid and sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) assay was developed and validated to quantify a… 
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