amrubicin

Known as: (+)-(7S,9S)-9-Acetyl-9-amino-7-((2-deoxy-beta-D-erythro-pentopyranosyl)oxy)- 6,11-dihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione 
A synthetic 9-amino-anthracycline with antineoplastic activity. Amrubicin intercalates into DNA and inhibits the activity of topoisomerase II… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2017
0102019992017

Papers overview

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2014
2014
PURPOSE Amrubicin, a third-generation anthracycline and potent topoisomerase II inhibitor, showed promising activity in small… (More)
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2014
2014
PURPOSE This randomized phase III trial was conducted to confirm noninferiority of amrubicin plus cisplatin (AP) compared with… (More)
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2011
2011
PURPOSE This phase II study evaluated the safety and efficacy of single-agent amrubicin versus topotecan in patients with small… (More)
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2010
2010
PURPOSE Amrubicin is a synthetic anthracycline with potent topoisomerase II inhibition. This phase II study was conducted to… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE Amrubicin, a new anthracycline agent, and topotecan are both active for previously treated small-cell lung cancer (SCLC… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE This multicenter, phase II study was conducted to evaluate the activity of amrubicin, a topoisomerase II inhibitor… (More)
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2006
2006
Purpose: To evaluate the efficacy and safety of amrubicin, (+)-(7S, 9S)-9-acetyl-9-amino-7-[(2-deoxy-β-D-erythro-pentopyranosyl… (More)
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2005
2005
BACKGROUND Amrubicin, a totally synthetic 9-amino-anthracycline, demonstrated excellent single-agent activity for extensive-stage… (More)
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Highly Cited
2005
Highly Cited
2005
The main anticancer action of doxorubicin (DOX) is believed to be due to topoisomerase II inhibition and free radical generation… (More)
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2005
2005
The in vitro metabolism of amrubicin by rat and human liver microsomes and cytosol was examined. The main metabolic routes in… (More)
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