Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.
Gene expression levels and immunolocalization of organic ion transporters in the human kidney.
Results suggest that hOOAT1, hOAT3, and hOCT2 play predominant roles in the transport of organic ions across the basolateral membrane of human proximal tubules.
Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.
- S. Masuda, T. Terada, K. Inui
- Biology, ChemistryJournal of the American Society of Nephrology
- 1 August 2006
Results indicate that hMATE2-K is a new human kidney-specific H+/organic cation antiporter that is responsible for the tubular secretion of cationic drugs across the brush border membranes.
Risk Factors for Prostate Cancer
- O. Ogawa
In the control of prostate cancer, the identification of risk factors and the promotion of active preventive medicine can provide enormous benefits to the super-aging society of the authors' future.
Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour
The IGF2 gene is expressed from the paternal allele in human fetal tissue, but that in Wilms' tumour expression can occur biallelically, providing the first evidence that relaxation of imprinting may play a role in the onset of disease.
Salt-sensitive hypertension in circadian clock–deficient Cry-null mice involves dysregulated adrenal Hsd3b6
Type VI 3β-hydroxyl-steroid dehydrogenase (Hsd3b6) is identified as a new hypertension risk factor in mice and placed in a pivotal position through which circadian clock malfunction is coupled to the development of hypertension.
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
A large-scale genome-wide association study in a Japanese population provides insights into the etiology of complex diseases and highlights the importance of performing GWAS in non-European populations.
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population
Five new loci for prostate cancer susceptibility are reported here, at 5p15 (λ-corrected probability PGC = 3.9 × 10−18), GPRC6A/RFX6 (PGC = 1.6 ×10−12), 13q22 ( PGC = 2.8 × 10–10−9), C2orf43 (PGD = 7.5 × 10.–8) and FOXP4 (PGE = 7−8).
Increased risk of prostate cancer and benign prostatic hyperplasia associated with a CYP17 gene polymorphism with a gene dosage effect.
The results suggest that the A1 allele of the CYP17 polymorphism is associated with an increased risk of prostate cancer and BPH, with a gene dosage effect, however, the CyP17 genotype does not seem to influence the disease status in prostate cancer.
Durvalumab alone and durvalumab plus tremelimumab versus chemotherapy in previously untreated patients with unresectable, locally advanced or metastatic urothelial carcinoma (DANUBE): a randomised,…