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Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.
HMATE1 and hMATE2-K function together as a detoxication system, by mediating the tubular secretion of intracellular ionic compounds across the brush-border membranes of the kidney.
Gene expression levels and immunolocalization of organic ion transporters in the human kidney.
Results suggest that hOOAT1, hOAT3, and hOCT2 play predominant roles in the transport of organic ions across the basolateral membrane of human proximal tubules.
Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.
Results indicate that hMATE2-K is a new human kidney-specific H+/organic cation antiporter that is responsible for the tubular secretion of cationic drugs across the brush border membranes.
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population
Five new loci for prostate cancer susceptibility are reported here, at 5p15 (λ-corrected probability PGC = 3.9 × 10−18), GPRC6A/RFX6 (PGC = 1.6 ×10−12), 13q22 ( PGC = 2.8 × 10–10−9), C2orf43 (PGD = 7.5 × 10.–8) and FOXP4 (PGE = 7−8).
Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour
The IGF2 gene is expressed from the paternal allele in human fetal tissue, but that in Wilms' tumour expression can occur biallelically, providing the first evidence that relaxation of imprinting may play a role in the onset of disease.
Risk Factors for Prostate Cancer
Prostate cancer is one of the representative cancers that show a marked difference in morbidity by race and region. In the U.S.A., the annual frequency for the diagnosis of prostate cancer is ranked
Salt-sensitive hypertension in circadian clock–deficient Cry-null mice involves dysregulated adrenal Hsd3b6
Type VI 3β-hydroxyl-steroid dehydrogenase (Hsd3b6) is identified as a new hypertension risk factor in mice and placed in a pivotal position through which circadian clock malfunction is coupled to the development of hypertension.
Increased risk of prostate cancer and benign prostatic hyperplasia associated with a CYP17 gene polymorphism with a gene dosage effect.
The results suggest that the A1 allele of the CYP17 polymorphism is associated with an increased risk of prostate cancer and BPH, with a gene dosage effect, however, the CyP17 genotype does not seem to influence the disease status in prostate cancer.
Distribution and genetic association of putative uropathogenic virulence factors iroN, iha, kpsMT, ompT and usp in Escherichia coli isolated from urinary tract infections in Japan.
Of the putative uropathogenic VFs examined, iroN, iha, kpsMT, ompT and usp were frequently associated with urinary tract infection.
Cyclin D1 gene polymorphism is associated with an increased risk of urinary bladder cancer.
The data suggest that the CCND1 variant A allele may be associated with an increased risk of TCC of the bladder, especially in men without a history of smoking, and it may also have an effect on its disease status.