amrubicin hydrochloride

Known as: (+)-(7S,9S)-9-Acetyl-9-amino-7-((2-deoxy-beta-D-erythro-pentopyranosyl)oxy)- 6,11-dihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride, Amirubicin Hydrochloride, (+)-(7S,9S)-9-acetyl-9-amino-7-((2-deoxy-beta-d-erythro-pentopyranosyl)oxy)-6,11-dihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride 
The hydrochloride salt of a third-generation synthetic 9-amino-anthracycline with antineoplastic activity. Amrubicin intercalates into DNA and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2018
02419992018

Papers overview

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2013
2013
BACKGROUND Amrubicin hydrochloride (AMR) is a key agent for lung cancer. NADPH quinone oxidoreductase 1 (NQO1) metabolizes the… (More)
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2012
2012
Antitumor anthracyclines such as doxorubicin and epirubicin are known to cause cardiotoxicity that correlates with anthracycline… (More)
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Review
2011
Review
2011
Lung cancer is the leading cause of cancer death, and approximately 15% of all lung cancer patients have small-cell lung cancer… (More)
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Review
2010
Review
2010
Long-term survival is quite uncommon in refractory small cell lung cancer (SCLC) patients, with less than 25% of patients with… (More)
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2008
2008
We retrospectively investigated monotherapy of amrubicin hydrochloride in patients with extensive-disease small cell lung cancer… (More)
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2006
2006
OBJECTIVE A single-center phase I trial was designed to determine both the dose-limiting toxicities and the maximum tolerated… (More)
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2005
2005
The in vitro metabolism of amrubicin by rat and human liver microsomes and cytosol was examined. The main metabolic routes in… (More)
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2005
2005
A fast computational electromagnetic (EM) simulator is invaluable, especially for trouble-shooting high-speed printed circuit… (More)
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2001
2001
An early phase II multi-center collaborative study of amrubicin hydrochloride, a novel synthetic anthracycline derivative… (More)
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1999
1999
It was reported that amrubicin hydrochloride (9-aminoanthracycline SM-5887), showed a higher therapeutic activity than… (More)
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