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Anthracyclines

Known as: Anthracyclines [Chemical/Ingredient], anthracycline 
Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.
National Institutes of Health

Related topics

Related topics

50 relations
10 ML Idarubicin Hydrochloride 1 MG/ML InjectionDoxorubicinDoxorubicin HydrochlorideEpirubicin Hydrochloride

Narrower (40)

11-deoxyoxaunomycin4-demethoxyanthracycline6-deoxyoxaunomycin8-demethoxysteffimycin

Papers overview

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1994
1994
Prodrugs of anthracyclines for chemotherapy via enzyme-monoclonal antibody conjugates.
New prodrugs of daunorubicin, 1c, 1e and 2c, including a galactopyranosyl residue linked to the N-3' of the daunosaminyl moiety… 
1987
1987
Anthracycline antibiotics. Interaction with DNA and nucleosomes and inhibition of DNA synthesis.
We report studies of the interaction of four anthracycline antibiotics, iremycin (IM), daunomycin (DM), aclacinomycin A (AM), and… 
1986
1986
Intensely potent anthracycline antibiotic oxaunomycin produced by a blocked mutant of the daunorubicin-producing microorganism.
A new potent anthracycline antibiotic oxaunomycin was isolated from the culture broth of a blocked mutant derived from a baumycin… 
1985
1985
Isolation and chemical structure of aklanonic acid, an early intermediate in the biosynthesis of anthracyclines.
The fermentation, isolation and structure elucidation of aklanonic acid are described. The compound was isolated from… 
Highly Cited
1985
Highly Cited
1985
Phase I and II clinical and pharmacological study of 4-demethoxydaunorubicin (idarubicin) in adult patients with acute leukemia.
Fifty-two adults treated previously with either acute leukemia (43 patients) or blastic-phase chronic myelogenous leukemia (nine… 
1984
1984
Akrobomycin, a new anthracycline antibiotic.
Biological activities of arugomycin and its analogues obtained by chemical degradation and modification were evaluated… 
Highly Cited
1983
Highly Cited
1983
Phase I and clinical pharmacology studies of intravenous and oral administration of 4-demethoxydaunorubicin in patients with advanced cancer.
4-Demethoxydaunorubicin (4-DMDR), an anthracycline analogue available in i.v. and p.o. form, has shown significant antitumor… 
1981
1981
Initial biotransformations of daunorubicin to aglycones by rat liver microsomes.
Anaerobic incubations of rat liver microsomes convert daunorubicin into at least six or seven aglycones in the presence of… 
1976
1976
Reductive microbial conversion of anthracycline antibiotics.
Reductive conversion of several anthracycline glycosides to their 7-deoxyaglycones occurs during their microaerophilic incubation… 
1975
1975
Microbial conversion of anthracycline antibiotics.
pathway was elucidated by YosHIMOro et al.2) from an analysis of the structures of anthracyclines produced during microbial…