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The purpose of this study was to evaluate the clinical relevance of anthracycline-induced cardiomyopathy (AC-CMP) and… Expand BACKGROUND
Quinquennial overviews (1985-2000) of the randomised trials in early breast cancer have assessed the 5 year and 10… Expand The clinical use of anthracyclines like doxorubicin and daunorubicin can be viewed as a sort of double-edged sword. On the one… Expand PURPOSE
Docetaxel and capecitabine, a tumor-activated oral fluoropyrimidine, show high single-agent efficacy in metastatic breast… Expand BACKGROUND
The HER2 gene, which encodes the growth factor receptor HER2, is amplified and HER2 is overexpressed in 25 to 30… Expand The mechanisms responsible for the antiproliferative and cytotoxic effects of the anthracycline antibiotics doxorubicin… Expand The anthracyclines are the class of antitumor drugs with the widest spectrum of activity in human cancers, and only a few cancers… Expand OBJECTIVE
--To assess the cardiac status of long-term survivors of pediatric malignancies who received chemotherapy, including… Expand In the present study we have used beef heart submitochondrial preparations (BH-SMP) to demonstrate that a component of… Expand PERHAPS no family of chemotherapeutic agents has been so rapidly accepted as a major therapeutic tool in treating patients with… Expand