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Doxorubicin

Known as: Hydroxyldaunorubicin, 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-, Doxorubicin [Chemical/Ingredient] 
An anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the… 
National Institutes of Health

Related topics

Related topics

48 relations
AC-T RegimenCDE protocol-cyclophosphamide/doxorubicin/etoposideCHVmP-VB protocolCOPP-ABV Regimen

Narrower (20)

ACP protocolCHOP protocol-cyclophosphamide/doxorubicin/prednisone/vincristineCISCA protocolDOXO-cell

Papers overview

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Highly Cited
2010
Highly Cited
2010
Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis…
Highly Cited
2008
Highly Cited
2008
Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy
Abnormal accumulation of myeloid-derived suppressor cells (MDSC) is an important mechanism of tumor immune evasion… 
Highly Cited
2006
Highly Cited
2006
A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas
The antitumor effect of doxorubicin (DOX) conjugated to a biodegradable dendrimer was evaluated in mice bearing C-26 colon… 
Highly Cited
2005
Highly Cited
2005
Chronic progressive cardiac dysfunction years after doxorubicin therapy for childhood acute lymphoblastic leukemia.
PURPOSE Cross-sectional studies show that cardiac abnormalities are common in long-term survivors of doxorubicin-treated… 
Highly Cited
2005
Highly Cited
2005
A randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma.
BACKGROUND Single-agent doxorubicin has been widely used to treat unresectable hepatocellular carcinoma (HCC), but the response… 
Highly Cited
2004
Highly Cited
2004
The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemia.
BACKGROUND Doxorubicin chemotherapy is very effective in children with acute lymphoblastic leukemia (ALL) but also injures… 
Review
1998
Review
1998
Doxorubicin-induced cardiomyopathy.
Doxorubicin (Adriamycin) has been used in oncologic practice since the late 1960s. It held promise as a powerful drug in the… 
Highly Cited
1998
Highly Cited
1998
Pegylated-liposomal doxorubicin versus doxorubicin, bleomycin, and vincristine in the treatment of AIDS-related Kaposi's sarcoma: results of a randomized phase III clinical trial.
PURPOSE Kaposi's sarcoma (KS), the most common neoplasm in patients with AIDS, is a significant clinical problem for which… 
Highly Cited
1991
Highly Cited
1991
Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukemia in childhood.
BACKGROUND Cardiotoxicity is a recognized complication of doxorubicin therapy, but the long-term effects of doxorubicin are not… 
Highly Cited
1977
Highly Cited
1977
Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response.
The antitumor antibiotic, adriamycin, induces severe cardiac toxicity associated with peroxidation of cardiac lipids in mice… 
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