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Molecular Determinants of Epidermal Growth Factor Binding: A Molecular Dynamics Study
Results reveal that while several residues are conserved among the EGFR ligand family, no single set of residues determines the affinity class, and heterogeneous sets of interactions that were driven primarily by electrostatic and Van der Waals forces are found.
Decorin Protein Core Inhibits in Vivo Cancer Growth and Metabolism by Hindering Epidermal Growth Factor Receptor Function and Triggering Apoptosis via Caspase-3 Activation*
In vitro studies showed that the uptake of decorin by the A431 cells was rapid and caused a protracted down-regulation of the EGFR to levels similar to those observed in the tumor xenografts, which could represent an additional mechanism whereby decorin might influence cell growth and survival.
Dosimetry of iodine-131 ethiodol in the treatment of hepatoma.
The results suggest that [131I]Ethiodol has the potential to deliver curative radiation doses to hepatomas with acceptable radiation burdens to normal tissues.
VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma.
Radiolabeled peptides in oncology: role in diagnosis and treatment.
Peptides have many key properties including fast clearance, rapid tissue penetration, and low antigenicity, and can be produced easily and inexpensively, but there may be problems with in vivo catabolism, unwanted physiologic effects, and chelate attachment.
CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines.
To determine the molecular mechanisms governing prostate cancer bone metastasis, FVB murine prostate epithelium was transduced with oncogenic v-Src andGene expression profiling of the tumors identified activation of a CCR5 signaling module when the prostate epithelial cell lines were grown in vivo versus tissue cultures.
Indium-111-labeled autologous leukocytes in man.
Autologous leukocytes have been isolated, labeled with indium-111, and administered to 15 patients suspected of inflammatory disease. The stability of the label has been demonstrated and the in vivo
Sentinel lymph nodes in a swine model with melanoma: contrast-enhanced lymphatic US.
Lymphatic US can depict metastases within the SLN, which was not possible with lymphoscintigraphy, and detection of SLNs with lymphatic US compared favorably with that at lymphoscintsigraphy.
Murine MPDZ‐linked hydrocephalus is caused by hyperpermeability of the choroid plexus
It is shown by magnetic resonance imaging that contrast medium penetrates into the brain ventricles of mice carrying a Mpdz loss‐of‐function mutation, whereas none is detected in the ventricle of normal mice, implying that the permeability of the choroid plexus epithelial cell monolayer is abnormally high.