Polymer micelles with cross-linked polyanion core for delivery of a cationic drug doxorubicin.

@article{Kim2009PolymerMW,
  title={Polymer micelles with cross-linked polyanion core for delivery of a cationic drug doxorubicin.},
  author={Jong Oh Kim and Alexander V Kabanov and Tatiana K. Bronich},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2009},
  volume={138 3},
  pages={197-204}
}
Polymer micelles with cross-linked ionic cores were prepared by using block ionomer complexes of poly(ethylene oxide)-b-poly(methacrylic acid) (PEO-b-PMA) copolymer and divalent metal cations as templates. Doxorubicin (DOX), an anthracycline anticancer drug, was successfully incorporated into the ionic cores of such micelles via electrostatic interactions. A substantial drug loading level (up to 50 w/w%) was achieved and it was strongly dependent on the structure of the cross-linked micelles… CONTINUE READING