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A general mechanism for microsomal activation of quinone anticancer agents to free radicals.
It is proposed that the intracellular activation of these quinone anticancer drugs to a free radical state may be primary to their cytotoxic activity.
Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase.
NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals.
- N. Bachur, S. L. Gordon, M. Gee, H. Kon
- Chemistry, BiologyProceedings of the National Academy of Sciences…
- 1 February 1979
It is postulate that the formation of the "site-specific free radical/ intermediate is central to the cytotoxic action of these antibiotics.
Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation.
Electron spin resonance studies show that the anthraquinone nucleus of the anthracycline is reversibly converted to a free radical semiquinone, which serves to shuttle electrons to oxygen in rat liver microsomes and heart sarcosomes.
Comparison and characterization of mammalian xenobiotic ketone reductases.
Comparative mammalian metabolism of adriamycin and daunorubicin.
Tissues, especially liver, have a great potential for glycosidic activity that is normally not exhibited, and in certain patients this may be an important mechanism of biotransformation, according to drug, organ, and species.
Mammalian carbonyl reductases.
Adriamycin metabolism in man. Evidence from urinary metabolites.
The human metabolism of adriamycin involved carbonyl reduction, reductive glycosidic cleavage, hydrolytic glyCosidic Cleavage, O-demethylation,O-sulfation, and O-beta-glucuronidation, the major enzymatic conversion occurring in the human.
Purification of the phytohemagglutinin family of proteins from red kidney beans (Phaseolus vulgaris) by affinity chromatography.