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alpha-naphthoflavone
Known as:
7,8-benzoflavone
National Institutes of Health
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1 relation
Broader (1)
Benzoflavones
Papers overview
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Highly Cited
2000
Highly Cited
2000
Human cytochrome P-450 3A4: in vitro drug-drug interaction patterns are substrate-dependent.
R. Wang
,
D. Newton
,
N. Liu
,
W. Atkins
,
A. Y. Lu
Drug Metabolism And Disposition
2000
Corpus ID: 14070893
Testosterone, terfenadine, midazolam, and nifedipine, four commonly used substrates for human cytochrome P-450 3A4 (CYP3A4), were…
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Highly Cited
1994
Highly Cited
1994
Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.
M. Shou
,
J. Grogan
,
+4 authors
K. Korzekwa
Biochemistry
1994
Corpus ID: 22366477
A unique characteristic of the CYP3A subfamily of cytochrome P450 enzymes is their ability to be activated by certain compounds…
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Highly Cited
1992
Highly Cited
1992
Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens.
T. Shimada
,
C. Yun
,
H. Yamazaki
,
J. Gautier
,
P. Beaune
,
F. Guengerich
Molecular Pharmacology
1992
Corpus ID: 22582441
Rat and human lung microsomal cytochrome P-450 (P-450) enzymes have been characterized with regard to their catalytic activities…
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Highly Cited
1989
Highly Cited
1989
Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.
M. Butler
,
M. Iwasaki
,
F. Guengerich
,
F. Kadlubar
Proceedings of the National Academy of Sciences…
1989
Corpus ID: 35344364
Aromatic amines are well known as occupational carcinogens and are found in cooked foods, tobacco smoke, synthetic fuels, and…
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Highly Cited
1989
Highly Cited
1989
Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.
T. Shimada
,
M. Iwasaki
,
M. Martín
,
F. Guengerich
Cancer Research
1989
Corpus ID: 13085853
A total of 57 procarcinogens was examined for induction of umu gene response in the chimeric plasmid pSK1002, carried in…
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Highly Cited
1985
Highly Cited
1985
Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism.
C. Atal
,
R. Dubey
,
J. Singh
Journal of Pharmacology and Experimental…
1985
Corpus ID: 25420013
Piperine, a major active component of black and long peppers, has been reported to enhance drug bioavailability. The present…
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Highly Cited
1984
Highly Cited
1984
An alternative 7-ethoxyresorufin O-deethylase activity assay: a continuous visible spectrophotometric method for measurement of cytochrome P-450 monooxygenase activity.
A. V. Klotz
,
J. Stegeman
,
C. Walsh
Analytical Biochemistry
1984
Corpus ID: 31719858
Highly Cited
1984
Highly Cited
1984
Inhibition of human estrogen synthetase (aromatase) by flavones.
J. Kellis
,
L. Vickery
Science
1984
Corpus ID: 24205886
Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to…
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Highly Cited
1976
Highly Cited
1976
Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.
E. Huberman
,
L. Sachs
,
S. K. Yang
,
V. Gelboin
Proceedings of the National Academy of Sciences…
1976
Corpus ID: 40650518
The mutagenicity of benzo[a]pyrene and 15 of its derivatives, which included phenols, the benzo[a]yrene-4,5-epoxide (the K-region…
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Highly Cited
1974
Highly Cited
1974
Cell‐mediated mutagenesis of mammalian cells with chemical carcinogens
E. Huberman
,
L. Sachs
International Journal of Cancer
1974
Corpus ID: 44787316
Chemically non‐reactive carcinogens, such as polycyclic hydrocarbons, have to be metabolized by cellular enzymes in order to…
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