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alpha-naphthoflavone

Known as: 7,8-benzoflavone 
National Institutes of Health

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Related topics

1 relation

Broader (1)

Benzoflavones

Papers overview

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Highly Cited
2000
Highly Cited
2000
Human cytochrome P-450 3A4: in vitro drug-drug interaction patterns are substrate-dependent.
Testosterone, terfenadine, midazolam, and nifedipine, four commonly used substrates for human cytochrome P-450 3A4 (CYP3A4), were… Expand
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Highly Cited
1994
Highly Cited
1994
Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.
A unique characteristic of the CYP3A subfamily of cytochrome P450 enzymes is their ability to be activated by certain compounds… Expand
Highly Cited
1992
Highly Cited
1992
Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens.
Rat and human lung microsomal cytochrome P-450 (P-450) enzymes have been characterized with regard to their catalytic activities… Expand
Highly Cited
1989
Highly Cited
1989
Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.
Aromatic amines are well known as occupational carcinogens and are found in cooked foods, tobacco smoke, synthetic fuels, and… Expand
Highly Cited
1989
Highly Cited
1989
Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.
In vitro studies with human liver indicate that the major catalyst involved in the bioactivation of the hepato-carcinogen… Expand
Highly Cited
1985
Highly Cited
1985
Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism.
Piperine, a major active component of black and long peppers, has been reported to enhance drug bioavailability. The present… Expand
Highly Cited
1984
Highly Cited
1984
Inhibition of human estrogen synthetase (aromatase) by flavones.
Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to… Expand
Highly Cited
1984
Highly Cited
1984
An alternative 7-ethoxyresorufin O-deethylase activity assay: a continuous visible spectrophotometric method for measurement of cytochrome P-450 monooxygenase activity.
A procedure to directly measure the cytochrome P-450-dependent 7-ethoxyresorufin O-deethylase activity with a visible… Expand
Highly Cited
1983
Highly Cited
1983
An aryl hydrocarbon hydroxylating hepatic cytochrome P-450 from the marine fish Stenotomus chrysops.
Hepatic microsomal cytochrome P-450 from the untreated coastal marine fish scup, Stenotomus chrysops, was solubilized and… Expand
Highly Cited
1976
Highly Cited
1976
Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.
The mutagenicity of benzo[a]pyrene and 15 of its derivatives, which included phenols, the benzo[a]yrene-4,5-epoxide (the K-region… Expand
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