alpha-naphthoflavone

Known as: 7,8-benzoflavone 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Benzoflavones

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds.
The flavonoid genistein and the benzo[c]quinolizinium MPB-07 have been shown to activate the cystic fibrosis transmembrane… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Human cytochrome P-450 3A4: in vitro drug-drug interaction patterns are substrate-dependent.
Testosterone, terfenadine, midazolam, and nifedipine, four commonly used substrates for human cytochrome P-450 3A4 (CYP3A4), were… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
1998
1998
Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor.
K02 (morpholine-urea-Phe-Hphe-vinylsulfone), a newly developed peptidomimetic, acts as a potent cysteine protease inhibitor… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 4
  • figure 3
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes.
1. We evaluated the specificity of 15 substrates and 14 inhibitors of the cytochrome P450s using nine human P450 forms expressed… (More)
Is this relevant?
1995
1995
Heterogenous effects of natural flavonoids on monooxygenase activities in human and rat liver microsomes.
The in vitro effects of nine flavonoids on different monooxygenase activities from human and rat liver were investigated… (More)
Is this relevant?
Highly Cited
1992
Highly Cited
1992
Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens.
Rat and human lung microsomal cytochrome P-450 (P-450) enzymes have been characterized with regard to their catalytic activities… (More)
Is this relevant?
Highly Cited
1989
Highly Cited
1989
Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.
Aromatic amines are well known as occupational carcinogens and are found in cooked foods, tobacco smoke, synthetic fuels, and… (More)
Is this relevant?
Highly Cited
1989
Highly Cited
1989
Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic…
Human liver microsomes oxidized 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene [B(a)P-7,8-diol] to products that yield DNA adduct… (More)
Is this relevant?
Highly Cited
1989
Highly Cited
1989
Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.
A total of 57 procarcinogens was examined for induction of umu gene response in the chimeric plasmid pSK1002, carried in… (More)
  • figure 1
  • table 2
  • figure 2
  • figure 3
  • table 3
Is this relevant?
Highly Cited
1981
Highly Cited
1981
Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids.
The effects of several naturally occurring and synthetic flavonoids on the metabolism of benzo(a)pyrene and aflatoxin B1 were… (More)
  • table 1
  • table 2
  • table 5
  • table 4
  • table 3
Is this relevant?