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alpha-naphthoflavone

Known as: 7,8-benzoflavone 
National Institutes of Health

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Broader (1)

Benzoflavones

Papers overview

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Highly Cited
2000
Highly Cited
2000
Human cytochrome P-450 3A4: in vitro drug-drug interaction patterns are substrate-dependent.
Testosterone, terfenadine, midazolam, and nifedipine, four commonly used substrates for human cytochrome P-450 3A4 (CYP3A4), were… 
Highly Cited
1994
Highly Cited
1994
Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.
A unique characteristic of the CYP3A subfamily of cytochrome P450 enzymes is their ability to be activated by certain compounds… 
Highly Cited
1992
Highly Cited
1992
Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens.
Rat and human lung microsomal cytochrome P-450 (P-450) enzymes have been characterized with regard to their catalytic activities… 
Highly Cited
1989
Highly Cited
1989
Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.
Aromatic amines are well known as occupational carcinogens and are found in cooked foods, tobacco smoke, synthetic fuels, and… 
Highly Cited
1989
Highly Cited
1989
Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.
A total of 57 procarcinogens was examined for induction of umu gene response in the chimeric plasmid pSK1002, carried in… 
Highly Cited
1985
Highly Cited
1985
Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism.
Piperine, a major active component of black and long peppers, has been reported to enhance drug bioavailability. The present… 
Highly Cited
1984
Highly Cited
1984
An alternative 7-ethoxyresorufin O-deethylase activity assay: a continuous visible spectrophotometric method for measurement of cytochrome P-450 monooxygenase activity.
Highly Cited
1984
Highly Cited
1984
Inhibition of human estrogen synthetase (aromatase) by flavones.
Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to… 
Highly Cited
1976
Highly Cited
1976
Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.
The mutagenicity of benzo[a]pyrene and 15 of its derivatives, which included phenols, the benzo[a]yrene-4,5-epoxide (the K-region… 
Highly Cited
1974
Highly Cited
1974
Cell‐mediated mutagenesis of mammalian cells with chemical carcinogens
Chemically non‐reactive carcinogens, such as polycyclic hydrocarbons, have to be metabolized by cellular enzymes in order to… 
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