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alpha-naphthoflavone

Known as: 7,8-benzoflavone 
National Institutes of Health

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Benzoflavones

Papers overview

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Highly Cited
1989
Highly Cited
1989
Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic…
Human liver microsomes oxidized 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene [B(a)P-7,8-diol] to products that yield DNA adduct… 
Highly Cited
1986
Highly Cited
1986
Effects of anti-promoters and strain of mouse on tumor promoter-induced oxidants in murine epidermal cells.
The induction of oxidant production in mouse epidermal cells by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) can… 
Highly Cited
1982
Highly Cited
1982
Differential effects of retinoic acid and 7,8-benzoflavone on the induction of mouse skin tumors by the complete carcinogenesis process and by the initiation-promotion regimen.
Abstract The present study was designed to elucidate differences in the mechanism of the induction of mouse skin tumors either by… 
Highly Cited
1982
Highly Cited
1982
Induction studies on the functional heterogeneity of rat liver UDP-glucuronosyltransferases.
Highly Cited
1981
Highly Cited
1981
Specificity in the activation and inhibition by flavonoids of benzo[a]pyrene hydroxylation by cytochrome P-450 isozymes from rabbit liver microsomes.
Highly Cited
1979
Highly Cited
1979
Aldrin epoxidation, a highly sensitive indicator specific for cytochrome P-450-dependent mono-oxygenase activities.
Aldrin epoxidation was studied in rat liver microsomes. The assay is very sensitive; amounts of less than 1 microgram of… 
Highly Cited
1976
Highly Cited
1976
Binding of metabolically activated benzo(a)pyrene to nuclear macromolecules.
The binding of metabolically activated [3H]benzo(a)pyrene ([3H]BP) to the DNA, RNA, histones, and nonhistones of isolated rat… 
Highly Cited
1974
Highly Cited
1974
Cell‐mediated mutagenesis of mammalian cells with chemical carcinogens
Chemically non‐reactive carcinogens, such as polycyclic hydrocarbons, have to be metabolized by cellular enzymes in order to… 
Highly Cited
1974
Highly Cited
1974
High-pressure liquid chromatographic analysis of benzo(alpha)pyrene metabolism and covalent binding and the mechanism of action of 7,8-benzoflavone and 1,2-epoxy-3,3,3-trichloropropane.
Summary High-pressure liquid chromatography is a rapid and efficient method for the separation of benzo(a)pyrene metabolites… 
Highly Cited
1972
Highly Cited
1972
The role of aryl hydrocarbon hydroxylase in 7,12-dimethylbenz(a)anthracene skin tumorigenesis: on the mechanism of 7,8-benzoflavone inhibition of tumorigenesis.
Summary Aryl hydrocarbon hydroxylase of mouse skin is inducible by benz(a)anthracene or 7,12-dimethylbenz(a)anthracene (DMBA) and… 
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