alpha 1-proteinase inhibitor, human

Known as: Alpha-1 Proteinase Inhibitor, Human, .alpha.1-proteinase Inhibitor Human, alpha1-proteinase inhibitor human 
Human serum-derived alpha-1 proteinase inhibitor (alpha-1-antitrypsin or AAT) with immunomodulating and anti-inflammatory activity. Upon… (More)
National Institutes of Health

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Alpha-1-antitrypsin measurementDrug AllergySERPINA1 genealpha 1-Antitrypsin Deficiency
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GlassiaProlastin

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alpha 1-Antitrypsin

Papers overview

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Review
2008
Review
2008
Hereditary alpha-1-antitrypsin deficiency and its clinical consequences
Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder that manifests as pulmonary emphysema, liver cirrhosis and, rarely… (More)
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Highly Cited
2007
Highly Cited
2007
Directed differentiation of human embryonic stem cells into functional hepatic cells.
UNLABELLED The differentiation capacity of human embryonic stem cells (hESCs) holds great promise for therapeutic applications… (More)
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Highly Cited
2006
Highly Cited
2006
alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis.
alpha-1 Antitrypsin (A1AT) is an abundant circulating serpin with a postulated function in the lung of potently inhibiting… (More)
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Highly Cited
2005
Highly Cited
2005
The metabolically healthy but obese individual presents a favorable inflammation profile.
OBJECTIVE The purpose of this study was to investigate the inflammatory state in obese women displaying the "metabolically… (More)
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Highly Cited
1997
Highly Cited
1997
Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein.
The Rho GDP dissociation inhibitor (GDI) forms a complex with the GDP-bound form of the Rho family small G proteins and inhibits… (More)
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Highly Cited
1992
Highly Cited
1992
The mechanism of Z alpha 1-antitrypsin accumulation in the liver.
Most northern Europeans have only the normal M form of the plasma protease inhibitor alpha 1-antitrypsin, but some 4% are… (More)
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Review
1988
Review
1988
Molecular basis of alpha-1-antitrypsin deficiency.
Alpha-1-antitrypsin (A1AT) deficiency is an autosomal hereditary disorder associated with a major reduction in serum A1AT levels… (More)
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Highly Cited
1987
Highly Cited
1987
Replacement therapy for alpha 1-antitrypsin deficiency associated with emphysema.
In patients with alpha 1-antitrypsin deficiency, the development of emphysema is believed to be caused by the unchecked action of… (More)
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Highly Cited
1986
Highly Cited
1986
Oxidative regulation of neutrophil elastase-alpha-1-proteinase inhibitor interactions.
Triggered human neutrophils were able to maintain released elastase in an active form in the presence of purified alpha-1… (More)
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1982
1982
Determination of oxidized alpha-1-proteinase inhibitor in serum.
When alpha-1-PI is oxidized, it loses its ability to inhibit porcine elastase, although it retains its TIC. Therefore the ratio… (More)
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