SERPINA1 gene

Known as: ANTITRYPSIN, A1AT, ANTI-ELASTASE 
This gene plays a role in both coagulation and the regulation of proteolysis.

Topic mentions per year

Topic mentions per year

1969-2018
020406019692018

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major… (More)
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Highly Cited
2012
Highly Cited
2012
Association testing of multiple correlated phenotypes offers better power than univariate analysis of single traits. We analyzed… (More)
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Highly Cited
2011
Highly Cited
2011
Human induced pluripotent stem cells (iPSCs) represent a unique opportunity for regenerative medicine because they offer the… (More)
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2008
2008
BACKGROUND Individuals with severe deficiency in serum alpha(1)-antitrypsin (AAT) concentrations are at high risk for developing… (More)
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2006
2006
Chronic obstructive pulmonary disease (COPD) is a major cause of mortality and morbidity worldwide. While cigarette smoking is a… (More)
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Highly Cited
2005
Highly Cited
2005
In alpha(1)-antitrypsin (alpha1AT) deficiency, a polymerogenic mutant form of the secretory glycoprotein alpha1AT, alpha1ATZ, is… (More)
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Highly Cited
2005
Highly Cited
2005
The study looked for an optimal set of genes differentiating between papillary thyroid cancer (PTC) and normal thyroid tissue and… (More)
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Highly Cited
2004
Highly Cited
2004
Conformational diseases are a class of disorders associated with aberrant protein accumulation in tissues and cellular… (More)
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2000
2000
Recent studies have suggested that macrophage-derived metalloproteases are the critical mediators of cigarette smoke-induced… (More)
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2000
2000
Airways inflammation in chronic bronchitis is thought predominantly to be a direct consequence of neutrophil recruitment and… (More)
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