alpha 1-Antitrypsin

Known as: Serine (or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1, Trypsin Inhibitor, alpha 1-Antitrypsin, alpha-1 antitrypsin 
Alpha-1-antitrypsin (418 aa, ~47 kDa) is encoded by the human SERPINA1 gene. This protein plays a role in regulation of proteolysis.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1965-2017
010020019652017

Papers overview

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Highly Cited
2000
Highly Cited
2000
In alpha1-AT deficiency, a misfolded but functionally active mutant alpha1-ATZ (alpha1-ATZ) molecule is retained in the… (More)
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Highly Cited
1998
Highly Cited
1998
Recombinant adeno-associated virus (AAV) vectors have been used to transduce murine skeletal muscle as a platform for secretion… (More)
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Highly Cited
1992
Highly Cited
1992
Most northern Europeans have only the normal M form of the plasma protease inhibitor alpha 1-antitrypsin, but some 4% are… (More)
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Highly Cited
1991
Highly Cited
1991
The respiratory epithelium is a potential site for somatic gene therapy for the common hereditary disorders alpha 1-antitrypsin… (More)
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Highly Cited
1991
Highly Cited
1991
In cystic fibrosis neutrophil-dominated inflammation on the respiratory epithelial surface results in a chronic epithelial burden… (More)
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Highly Cited
1989
Highly Cited
1989
We have improved the "polymerase chain reaction" (PCR) to permit rapid analysis of any known mutation in genomic DNA. We… (More)
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Highly Cited
1989
Highly Cited
1989
Transthyretin (TTR) and alpha 1-antitrypsin (alpha 1-AT) are expressed at high levels in the liver and also in at least one other… (More)
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Highly Cited
1987
Highly Cited
1987
In patients with alpha 1-antitrypsin deficiency, the development of emphysema is believed to be caused by the unchecked action of… (More)
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Highly Cited
1986
Highly Cited
1986
Previous reports have suggested an association between homozygous alpha 1-antitrypsin deficiency, cirrhosis, and primary liver… (More)
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Highly Cited
1985
Highly Cited
1985
From 1970 to 1983, 69 individuals (aged from infancy to 87 years) with homozygous alpha 1-antitrypsin deficiency (ZZ) were… (More)
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