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alpha 1-Antitrypsin
Known as:
Serine (or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1
, Trypsin Inhibitor, alpha 1-Antitrypsin
, alpha-1 antitrypsin
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Alpha-1-antitrypsin (418 aa, ~47 kDa) is encoded by the human SERPINA1 gene. This protein plays a role in regulation of proteolysis.
National Institutes of Health
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Related topics
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32 relations
Alpha 1 antitrypsin Ag:PrThr:Pt:Tiss:Ord:Immune stain
Alpha 1 antitrypsin:MCnc:Pt:Stool:Qn
Alpha 1 antitrypsin:MCnt:24H:Stool:Qn
Alpha 1 antitrypsin:MCnt:72H:Stool:Qn
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Narrower (9)
C105Y peptide
Glassia
Prolastin
UBE peptide, mouse
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Broader (3)
Pancreatic Elastase
Serine Proteinase Inhibitors
Trypsin Inhibitors
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1995
Highly Cited
1995
Stromelysin-3 is overexpressed by stromal elements in primary non-small cell lung cancers and regulated by retinoic acid in pulmonary fibroblasts.
I. Anderson
,
D. Sugarbaker
,
+5 authors
M. Shipp
Cancer Research
1995
Corpus ID: 14581075
Stromelysin-3 (STR-3) is a recently characterized matrix metalloproteinase (MMP) that was cloned on the basis of differential…
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Highly Cited
1994
Highly Cited
1994
Purification and characterization of a collagen-degrading protease from Porphyromonas gingivalis.
Gurrinder
,
BediS
,
Taffy Williams
Journal of Biological Chemistry
1994
Corpus ID: 21009637
Highly Cited
1994
Highly Cited
1994
Corneal synthesis of alpha 1-proteinase inhibitor (alpha 1-antitrypsin).
S. Twining
,
T. Fukuchi
,
B. Yue
,
P. M. Wilson
,
G. Bošković
Investigative Ophthalmology and Visual Science
1994
Corpus ID: 28012411
PURPOSE To determine if the cornea synthesizes alpha 1-proteinase inhibitor (alpha 1-antitrypsin). METHODS Human corneas were…
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Highly Cited
1992
Highly Cited
1992
Inactivation of alpha 1-proteinase inhibitor by peroxynitrite.
J. J. Moreno
,
W. Pryor
Chemical Research in Toxicology
1992
Corpus ID: 19130089
We here report the reactions of peroxynitrite (O=NOO-) with alpha 1-proteinase inhibitor (alpha 1PI) and with a synthetic…
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Highly Cited
1992
Highly Cited
1992
Proteolytic inactivation of alpha 1-proteinase inhibitor and alpha 1-antichymotrypsin by oxidatively activated human neutrophil metalloproteinases.
P. E. Desrochers
,
K. Mookhtiar
,
H. E. V. Wart
,
K. Hasty
,
S. J. Weiss
Journal of Biological Chemistry
1992
Corpus ID: 24217029
Highly Cited
1990
Highly Cited
1990
Interactions of human mast cell tryptase with biological protease inhibitors.
S. Alter
,
J. Kramps
,
A. Janoff
,
L. Schwartz
Archives of Biochemistry and Biophysics
1990
Corpus ID: 22340599
Highly Cited
1990
Highly Cited
1990
Determination of plasma protein C inhibitor and of two activated protein C-inhibitor complexes in normals and in patients with intravascular coagulation and thrombotic disease.
Francisco España
,
Vicente Vicente
,
Dolores Tabernero
,
Inge Scharrer
,
John H. Griffin
Thrombosis Research
1990
Corpus ID: 1742609
Highly Cited
1987
Highly Cited
1987
The antioxidant action of human extracellular fluids. Effect of human serum and its protein components on the inactivation of alpha 1-antiproteinase by hypochlorous acid and by hydrogen peroxide.
M. Wasil
,
B. Halliwell
,
D. Hutchison
,
H. Baum
Biochemical Journal
1987
Corpus ID: 763828
The elastase-inhibitory capacity of purified human alpha 1-antiproteinase is inactivated by low concentrations of the…
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Highly Cited
1980
Highly Cited
1980
Potential mediator of inflammation. Phagocyte-derived oxidants suppress the elastase-inhibitory capacity of alpha 1-proteinase inhibitor in vitro.
H. Carp
,
A. Janoff
Journal of Clinical Investigation
1980
Corpus ID: 17423861
Human polymorphonuclear leukocytes, monocytes, or pulmonary alveolar macrophages, stimulated in vitro by phorbol myristate…
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Highly Cited
1979
Highly Cited
1979
Purification of human plasma alpha 2 macroglobulin and alpha 1 proteinase inhibitor using zinc chelate chromatography.
T. Kurecki
,
L. F. Kress
,
M. Laskowski
Analytical Biochemistry
1979
Corpus ID: 32562483
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