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alpha 1-Antitrypsin

Known as: Serine (or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1, Trypsin Inhibitor, alpha 1-Antitrypsin, alpha-1 antitrypsin 
Alpha-1-antitrypsin (418 aa, ~47 kDa) is encoded by the human SERPINA1 gene. This protein plays a role in regulation of proteolysis.
National Institutes of Health

Related topics

Related topics

32 relations
Alpha 1 antitrypsin Ag:PrThr:Pt:Tiss:Ord:Immune stainAlpha 1 antitrypsin:MCnc:Pt:Stool:QnAlpha 1 antitrypsin:MCnt:24H:Stool:QnAlpha 1 antitrypsin:MCnt:72H:Stool:Qn

Narrower (9)

C105Y peptideGlassiaProlastinUBE peptide, mouse

Broader (3)

Pancreatic ElastaseSerine Proteinase InhibitorsTrypsin Inhibitors

Papers overview

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Highly Cited
1995
Highly Cited
1995
Stromelysin-3 is overexpressed by stromal elements in primary non-small cell lung cancers and regulated by retinoic acid in pulmonary fibroblasts.
Stromelysin-3 (STR-3) is a recently characterized matrix metalloproteinase (MMP) that was cloned on the basis of differential… 
Highly Cited
1994
Highly Cited
1994
Purification and characterization of a collagen-degrading protease from Porphyromonas gingivalis.
Highly Cited
1994
Highly Cited
1994
Corneal synthesis of alpha 1-proteinase inhibitor (alpha 1-antitrypsin).
PURPOSE To determine if the cornea synthesizes alpha 1-proteinase inhibitor (alpha 1-antitrypsin). METHODS Human corneas were… 
Highly Cited
1992
Highly Cited
1992
Inactivation of alpha 1-proteinase inhibitor by peroxynitrite.
We here report the reactions of peroxynitrite (O=NOO-) with alpha 1-proteinase inhibitor (alpha 1PI) and with a synthetic… 
Highly Cited
1992
Highly Cited
1992
Proteolytic inactivation of alpha 1-proteinase inhibitor and alpha 1-antichymotrypsin by oxidatively activated human neutrophil metalloproteinases.
Highly Cited
1990
Highly Cited
1990
Interactions of human mast cell tryptase with biological protease inhibitors.
Highly Cited
1990
Highly Cited
1990
Determination of plasma protein C inhibitor and of two activated protein C-inhibitor complexes in normals and in patients with intravascular coagulation and thrombotic disease.
Highly Cited
1987
Highly Cited
1987
The antioxidant action of human extracellular fluids. Effect of human serum and its protein components on the inactivation of alpha 1-antiproteinase by hypochlorous acid and by hydrogen peroxide.
The elastase-inhibitory capacity of purified human alpha 1-antiproteinase is inactivated by low concentrations of the… 
Highly Cited
1980
Highly Cited
1980
Potential mediator of inflammation. Phagocyte-derived oxidants suppress the elastase-inhibitory capacity of alpha 1-proteinase inhibitor in vitro.
Human polymorphonuclear leukocytes, monocytes, or pulmonary alveolar macrophages, stimulated in vitro by phorbol myristate… 
Highly Cited
1979
Highly Cited
1979
Purification of human plasma alpha 2 macroglobulin and alpha 1 proteinase inhibitor using zinc chelate chromatography.
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