• Publications
  • Influence
Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that impair the function of CFTR, an epithelial chloride channel required for proper function ofExpand
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Test anxiety and direction of attention.
  • J. Wine
  • Psychology, Medicine
  • Psychological bulletin
  • 1 August 1971
The literature reviewed suggests an attentional interpretation, of the adverse effects which test anxiety has on task performance. During task performance the highly test-anxious person divides hisExpand
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Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl- secretion.
Of 12 cell lines derived from human lung cancers, only Calu-3 cells showed high transepithelial resistance (Rte) and increases in short-circuit current (Isc) in response to mediators. Calu-3 cellsExpand
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The organization of escape behaviour in the crayfish.
  • J. Wine, F. Krasne
  • Biology, Medicine
  • The Journal of experimental biology
  • 1 February 1972
1. Examination of escape behaviour in freely moving animals with chronically implanted nerve cord electrodes has clarified the normal function of the giant fibres and the general organization ofExpand
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Swelling-induced and depolarization-induced C1-channels in normal and cystic fibrosis epithelial cells.
  • C. Solc, J. Wine
  • Chemistry, Medicine
  • The American journal of physiology
  • 1 October 1991
Cl- currents induced by cell swelling were characterized at the whole cell and single-channel levels in primary cultures of normal and cystic fibrosis (CF) epithelial cells and in the T84 cell line.Expand
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Delta F508-CFTR channels: kinetics, activation by forskolin, and potentiation by xanthines.
Trafficking, activation, and kinetics of delta F508-cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR were compared in stably transduced C127I mouse mammary epithelial cells.Expand
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Airway Gland Structure and Function.
Submucosal glands contribute to airway surface liquid (ASL), a film that protects all airway surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B, and hundreds ofExpand
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Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis.
Cystic fibrosis (CF) is a recessive disease that affects multiple organs. It is caused by mutations in CFTR. Animal modeling of this disease has been challenging, with species- and strain-specificExpand
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CFTR in Calu-3 human airway cells: channel properties and role in cAMP-activated Cl- conductance.
Calu-3, a cell line derived from a lung adenocarcinoma, forms tight junctions, expresses cystic fibrosis transmembrane conductance regulator (CFTR), and secretes Cl- in response to adenosineExpand
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