alosetron

Known as: 2,3,4,5-Tetrahydro-5-methyl-2-((5-methyl-1H-imidazol-4-yl)methyl)-1H-pyrido(4,3-b)indol-1-one, alosetron [Chemical/Ingredient] 
A potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system… (More)
National Institutes of Health

Papers overview

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Review
2007
Review
2007
Serotonin is an important gastrointestinal signaling molecule. It is a paracrine messenger utilized by enterochromaffin (EC… (More)
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Highly Cited
2004
Highly Cited
2004
To evaluate therapies available for the treatment of irritable bowel syndrome, and provide consensus recommendations for their… (More)
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Highly Cited
2003
Highly Cited
2003
The 5HT3 receptor antagonist alosetron has been tested in several trials on irritable bowel syndrome (IBS) patients. The aim of… (More)
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Highly Cited
2001
Highly Cited
2001
OBJECTIVES:Bowel urgency is one of the most bothersome symptoms for nonconstipated IBS patients. The efficacy of alosetron in… (More)
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2001
2001
Irritable bowel syndrome (IBS) is one of the most common entities observed by both primary care physicians and… (More)
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2001
2001
BACKGROUND Functional dyspepsia is characterized by upper abdominal pain or discomfort. AIM To assess the benefit of the 5-HT3… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Irritable bowel syndrome (IBS) is a common gastrointestinal disorder with symptoms of abdominal pain, discomfort, and… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Noxious intestinal distention elicits a reflex depressor response in the sodium pentobarbitone anaesthetised rat… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND No currently available treatment provides consistent relief of irritable bowel syndrome. Colonic sensory and motor… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Visceral hypersensitivity plays a major role in the pathophysiology of irritable bowel syndrome, as shown by balloon… (More)
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