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alosetron

Known as: 2,3,4,5-Tetrahydro-5-methyl-2-((5-methyl-1H-imidazol-4-yl)methyl)-1H-pyrido(4,3-b)indol-1-one, alosetron [Chemical/Ingredient] 
A potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system… 
National Institutes of Health

Related topics

Related topics

22 relations
Abdominal PainColitis, IschemicConstipationCrohn Disease

Broader (3)

CarbolinesGastrointestinal AgentsSerotonin Antagonists

Narrower (3)

GR 68755Lotronexalosetron hydrochloride

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Increased muscarinic receptor activity of airway smooth muscle isolated from a mouse model of allergic asthma.
2010
2010
Reply
to the capsulorhexis Miayke et al. described the long-term clinical outcomes of toric intraocular lens (IOL) implantation in… 
2007
2007
Effect of ramosetron on conditioned emotional stress-induced colonic dysfunction as a model of irritable bowel syndrome in rats.
2005
2005
The effects of the 5‐HT3 antagonist, alosetron, on brain serotonin synthesis in patients with irritable bowel syndrome
Abstract  Serotonin (5‐HT) plays an important role in the pathophysiology of irritable bowel syndrome (IBS). Using α‐[11C]methyl… 
2004
2004
Central Modulation of Rectal Distension-Induced Blood Pressure Changes by Alosetron, A 5-HT3 Receptor Antagonist
Irritable bowel syndrome (IBS) represents one ofthe most common gastrointestinal-related diagnoses.Although the precise etiologic… 
2003
2003
Regulatory role of 5-HT and muscarinic receptor antagonists on the migrating myoelectric complex in rats.
2001
2001
Tolerability and safety of alosetron during long-term administration in female and male irritable bowel syndrome patients
OBJECTIVES:Alosetron (Lotronex) is a new therapeutic agent for irritable bowel syndrome (IBS) in women with diarrhea-predominant… 
Review
2001
Review
2001
Irritable bowel syndrome: new agents targeting serotonin receptor subtypes.
Although the past few years have seen an exponential growth of compounds of potential interest for the treatment of functional… 
Review
2000
Review
2000
Pharmacology and clinical experience with alosetron
Alosetron (Lotronex) is a potent, highly selective 5-HT3 antagonist. Animal models have shown it to be active in anxiety… 
Review
1999
Review
1999
Review article: clinical pharmacology of alosetron
Alosetron, a new 5‐HT3 antagonist is in development for the treatment of the irritable bowel syndrome. A series of randomized… 
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