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Tau PET imaging in neurodegenerative tauopathies—still a challenge
TLDR
Findings from in vitro and in vivo studies using both initial and new tau ligands are described and discussed, including their relation to biomarkers for amyloid-β and neurodegeneration, and cognitive findings.
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Receptor alterations in manganese intoxicated monkeys
TLDR
The results indicate that postsynaptic structures containing D1 receptors are sensitive while cells containing D2 receptors are either spared or compensated for by up-regulation of the number of receptors on remaining sites.
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Bile acids: short and long term effects in the intestine
TLDR
There is no firm evidence that clinically relevant concentrations of bile acids induce colon cancer, but Alterations in bile acid metabolism may be involved in the pathophysiology of constipation.
View on Taylor & Francis
Tolterodine – a new bladder-selective antimuscarinic agent
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Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization
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Cholinergic mechanisms in pain and analgesia.
TLDR
Clinically, the centrally active cholinesterase inhibitor physostigmine has been shown to give postoperative pain relief although of short duration and a muscarinic interneuron may explain the interactions with other neurotransmitters.
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Quantitative localization of human brain monoamine oxidase B by large section autoradiography using l-[3H]deprenyl
View on Elsevier
Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue.
TLDR
A multiple binding site model for the amyloid tracers (binding sites 1, 2 and 3), where AV-45, florbetapir, AV-1 (florbetaben), and Pittsburgh compound B, all show nanomolar affinity for the high-affinity site (binding site 1), as visualized by positron emission tomography.
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Autoradiographic distribution of [3H]acetylcholine binding sites in the cervical spinal cord of man and some other species
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Monoamine oxidase B in brains from patients with Alzheimer's disease: A biochemical and autoradiographical study
View on Elsevier
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