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alnespirone

Known as: (+)-(S)-N-(4-((5-methoxy-3-chromanyl)propylamino)butyl)-1,1-cyclopentanediacetimide, 4-(N-(5-methoxychroman-3-yl)-N-propylamino)butyl-8-azaspiro(4,5)decane-7,9-dione, 8-(4-(N-(5-methoxychroman-3-yl)-N-propyl)aminobutyl)-8-azaspiro(4,5)decane-7,9-dione 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (4)

Anti-Anxiety AgentsDopamine AgonistsSerotonin AgonistsSpiro Compounds

Narrower (3)

S 20244S 20499S 20500

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Activation of serotonergic neurotransmission during the performance of aggressive behavior in rats.
High aggression is often linked to lowered serotonin (5-HT) neurotransmission. Although this may hold for high aggression as a… 
2003
2003
5-HT1A agonists: alcohol drinking in rats and squirrel monkeys
RationaleIncreased alcohol intake after administration of low doses of 5-HT1A agonists is thought to be due to a reduction in 5… 
Highly Cited
2001
Highly Cited
2001
Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression
2000
2000
Alnespirone and buspirone have anxiolytic‐like effects in a conflict procedure in rats by stimulating 5‐HT1A receptors
We studied the anxiolytic‐like activity of alnespirone and buspirone, two 5‐HT1A receptor agonists, in a modified Geller–Seifter… 
1999
1999
Differential Regulation of Somatodendritic Serotonin 5‐HT1A Receptors by 2‐Week Treatments with the Selective Agonists Alnespirone (S‐20499) and 8‐Hydroxy‐2‐(Di‐n‐Propylamino)tetralin
Abstract : Single treatment with the serotonin (5‐hydroxytryptamine) 5‐HT1A receptor agonists 8‐hydroxy‐2‐(di‐n‐propylamino… 
1999
1999
Prevention by 5-HT1A receptor agonists of restraint stress- and yohimbine-induced release of cholecystokinin in the frontal cortex of the freely moving rat
1999
1999
Alnespirone (S 20499), an Agonist of 5-HT1A Receptors, and Imipramine Have Similar Activity in a Chronic Mild Stress Model of Depression
1998
1998
A Comparison of the Oxytocin and Vasopressin Responses to the 5-HT1A Agonist and Potential Anxiolytic Drug Alnespirone (S-20499)
1998
1998
Antidepressant-like effects of alnespirone (S 20499) in the learned helplessness test in rats.
Highly Cited
1997
Highly Cited
1997
The effect of the selective 5‐HT1A agonists alnespirone (S‐20499) and 8‐OH‐DPAT on extracellular 5‐hydroxytryptamine in different regions of rat brain
1 We have examined the effects of the systemic administration of the selective 5‐HT1A agonist alnespirone (S‐20499) on in vivo 5… 
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