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Neuron-specific enolase and chromogranin A as markers of neuroendocrine tumours.
TLDR
It is suggested that CgA ought to be the only general marker screened in NET patients, as it appeared to be a better marker of tumour evolution than NSE in patients followed for 11-37 months. Expand
Role of endogenous endothelin in chronic heart failure: effect of long-term treatment with an endothelin antagonist on survival, hemodynamics, and cardiac remodeling.
TLDR
Long-term treatment with an ET antagonist markedly increases survival in this rat model of CHF, and this increase in survival is associated with decreases in both preload and afterload and an increase in cardiac output as well as decreased LV hypertrophy, LV dilatation, and cardiac fibrosis. Expand
Production and characterization of four anti-neuropeptide Y monoclonal antibodies.
TLDR
Four monoclonal antibodies directed against various epitopes of neuropeptide Y demonstrate the presence of at least four epitopes on hNPY, two of them being continuous. Expand
Normal serum neuron specific enolase (NSE) value after the first cycle of chemotherapy
TLDR
The authors decided to assess the predictive value, in terms of complete response and survival, of serum NSE measured before and after one cycle of chemotherapy in patients with SCLC. Expand
Long-term follow-up of ifosfamide renal toxicity in children treated for malignant mesenchymal tumors: an International Society of Pediatric Oncology report.
TLDR
The renal function of 74 children with malignant mesenchymal tumors in complete remission and who have received the same ifosfamide chemotherapy protocol were studied 1 year after the completion of treatment, finding severe toxicity was correlated with the higher cumulative dose of 60 g/m2 of ifosFamide, a younger age (less than 2 1/2 years old), and a predominance of vesicoprostatic tumor involvement. Expand
Malignant pheochromocytoma: Clinical, biological, histologic and therapeutic data in a series of 20 patients with distant metastases
TLDR
Response to therapy was poor and warrants further cooperative trials, and high dopamine, methoxytyramine and homovanilic acid excretion levels seemed to correlate with large tumors or terminal stage. Expand
Screening for multiple endocrine neoplasia type 1 and hormonal production in apparently sporadic neuroendocrine tumors.
TLDR
MEN1 is a rare event in patients presenting with apparently sporadic neuroendocrine tumors (NET) and should be screened for by serum calcium and PTH-(1-84) measurements. Expand
Locally formed 5-hydroxytryptamine stimulates phosphate transport in cultured opossum kidney cells and in rat kidney.
TLDR
Locally generated 5-HT blunts the inhibitory effect of PTH on Na-P(i) co-transport in OK cells and endogenous 5- HT decreases P( i) excretion in rats, indicating that5-HT is a paracrine modulator involved in the physiological regulation of renal P(o) transport. Expand
Plasma neuropeptide Y concentrations in patients with neuroendocrine tumors.
TLDR
It is concluded that patients with neuroendocrine tumors, especially secreting and or malignant tumors of the sympathochromaffin system, often have elevated plasma NPY concentrations, the highest plasma levels being found in patients with malignant pheochromocytomas. Expand
Biochemical tests for diagnosis of phaeochromocytoma: urinary versus plasma determinations.
TLDR
It is suggested that urinary biochemical determinations--particularly of metanephrines--are more reliable than plasma catecholamine measurements as a test for phaeochromocytoma, and is particularly useful in patients with intermittent hypertension. Expand
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